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The promise of radiotherapy in high-risk non-muscle invasive bladder cancer

Bola, B.
; 
Hoskin, P. J.
; 
Sangar, V.
; 
Choudhury, A.
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Abstract
Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standard of care for non-muscle invasive bladder cancer (NMIBC), despite being routinely used in muscle invasive bladder cancer. Modern techniques and advances in technology mean that radiotherapy can be delivered with increased precision in reducing normal tissue damage. Developing novel biomarker approaches, together with combination approaches with radiosensitisers and other systemic treatments, means that radiotherapy could offer greater benefits than current treatments with BCG or surgery. This review summarises the current landscape and future potential of radiotherapy for high-risk NMIBC.
Authors
Bola, B.
Hoskin, P. J.
Sangar, V.
Choudhury, A.
Affiliation
Mersey and West Lancashire Teaching Hospitals Trust, Whiston Hospital, Warrington Road, Prescot L35 5DR, UK. The Genito Urinary Cancer Group, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, UK. Translational Radiobiology Group, Division of Cancer Sciences, The Oglesby Cancer Research Building, The University of Manchester, 555 Wilmslow Road, Manchester M20 4GJ, UK. The Department of Clinical Oncology, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, UK. Manchester Foundation Trust, Wythenshawe Hospital, Southmoor Road, Wythenshawe, Manchester M23 9LT, UK.
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2025
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All Christie Publications
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Bola B, Hoskin PJ, Sangar V, Choudhury A. The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer. Cancers (Basel). 2025 Feb 13;17(4). PubMed PMID: 40002223. Pubmed Central PMCID: PMC11853320. Epub 2025/02/26. eng.
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https://christie.openrepository.com/handle/10541/628181
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