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Spatial transcriptomics of the tumor microenvironment discriminates inflamed tumors responsive or resistant to atezolizumab plus bevacizumab in patients with advanced HCC

Pique-Gil, M.
; 
Vila-Escoda, A.
; 
Casado-Pelaez, M.
; 
Pinyol, R.
; 
Sande, A. H. D.
; 
Davalos, V.
; 
Gris-Oliver, A.
; 
Montironi, C.
; 
Peix, J.
; 
Porta-Pardo, E.
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Abstract
Authors
Pique-Gil, M.
Vila-Escoda, A.
Casado-Pelaez, M.
Pinyol, R.
Sande, A. H. D.
Davalos, V.
Gris-Oliver, A.
Montironi, C.
Peix, J.
Porta-Pardo, E.
Grases, D.
Cappuyns, S.
Mauro, E.
Cano-Segarra, G.
Figueiredo, I.
Ioannou, G.
Gonzalez-Kozlova, E.
Meyer, T.
Lachenmayer, A.
Marquardt, J. U.
Reeves, H.
Edeline, J.
Finkelmeier, F.
Trojan, J.
Blanc, J. F.
Hubner, R.
Pinter, M.
Luedde, T.
Vogel, A.
Gnjatic, S.
Sia, D.
Mazzaferro, V.
Dekervel, J.
Esteller, M.
Llovet, J. M.
Affiliation
Univ Barcelona, Liver Canc Translat Res Grp, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Hosp Clin,Liver Unit,Liver Canc Translat Res, Barcelona, Catalonia, Spain Josep Carreras Leukaemia Res Inst IJC, Chromatin Biol Grp, Barcelona 08916, Spain Hosp Clin Barcelona, ICMHO, Hematol Dept, Barcelona, Spain Josep Carreras Leukemia Res Inst IJC, Barcelona, Spain Barcelona Supercomp Ctr BSC, Barcelona, Spain Univ Hosp Leuven, Dept Gastroenterol, Leuven, Belgium Katholieke Univ Leuven, Lab Clin Digest Oncol, Dept Digest Oncol, Leuven, Belgium Katholieke Univ Leuven, Dept Human Genet, Lab Translat Genet, Leuven, Belgium VIB, Leuven, Belgium Drone Hopper Co, Res Ctr, Madrid, Spain Icahn Sch Med Mt Sinai, Dept ofMedicine, New York, NY 10029 USA UCL, Royal Free Hosp, Canc Inst, London, England Univ Hosp Bern, Univ Bern, Dept Anaesthesiol & Pain Med, Inselspital, Bern, Switzerland Univ Med Ctr Schleswig Holstein UKSH, Dept Pathol, Campus Lubeck, Lubeck, Germany Newcastle Univ, Ctr Canc, Newcastle Upon Tyne, England Newcastle Univ, Biosci Inst, Fac Med Sci, Newcastle Upon Tyne, Northumberland, England Newcastle Tyne Hosp NHS Fdn Trust, Newcastle Upon Tyne, Northumberland, England Ctr Euge ne Marquis, Rennes, France Frankfurt Univ Clin, Univ Liver & Canc Ctr, Dept Gastroenterol, Frankfurt, Germany CHU Bordeaux, Hop Haut Leveque, Dept Pathol, F-33604 Pessac, France Christie NHS Fdn Trust, Dept Med Oncol, Wilmslow Rd, Manchester M20 4BX, Lancashire, England Med Univ Vienna, Dept Med III, Div Endocrinol & Metab, Vienna, Austria Heinrich Heine Univ Dusseldorf, Med Fac, Univ Hosp Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, D-40225 Dusseldorf, Germany Hannover Med Sch, Dept Gastroenterol Hepatol & Endocrinol, Carl Neubergstr 1, Hannover, Germany Toronto Gen Hosp, Dept Gastroenterol & Hepatol, Toronto, ON, Canada Icahn Sch Med Mt Sinai, Tisch Canc Inst, Div Liver Dis, Mt Sinai Liver Canc Program, New York, NY 10029 USA Univ Milan, HPB Surg Hepatol & Liver Transplantat, Fdn IRCCS Ist Nazl Tumori Milano, Dept Oncol & Hematooncol, I-20133 Milan, Italy Agbar Innovac, Barcelona, Spain Univ Barcelona, Sch Med, Dept Physiol Sci 2, Barcelona, Spain
Description
Date
2025
Publisher
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All Christie Publications
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Keywords
Type
Meetings and Proceedings
Citation
Pique-Gil M, Vila-Escoda A, Casado-Pelaez M, Pinyol R, Sande AHD, Davalos V, et al. Spatial transcriptomics of the tumor microenvironment discriminates inflamed tumors responsive or resistant to atezolizumab plus bevacizumab in patients with advanced HCC. Journal of hepatology. 2025 MAY;82. PubMed PMID: WOS:001504520300044. English.
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URI
https://christie.openrepository.com/handle/10541/628115
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