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A phase 1, first-in-human, dose-escalation study of JNJ-74856665 (dihydroorotate dehydrogenase inhibitor) alone or in combination in patients with AML or MDS

Searle, E.
; 
Cluzeau, T.
; 
O'Nions, J.
; 
Recher, C.
; 
Gyan, E.
; 
Morillo, D.
; 
Esteve, J.
; 
Kulasekararaj, A.
; 
Raffoux, E.
; 
Walter, H. S.
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Abstract
Authors
Searle, E.
Cluzeau, T.
O'Nions, J.
Recher, C.
Gyan, E.
Morillo, D.
Esteve, J.
Kulasekararaj, A.
Raffoux, E.
Walter, H. S.
Pigneux, A.
Valcárcel, D.
Daskalakis, N.
Bussolari, J.
Pietsch, E. C.
Kuduk, S.
Bush, T.
Zhang, X.
Philippar, U.
Oluwasanjo, A.
Bradford, K.
Miller, J.
Van Bogaert, C.
Curtis, M.
Chang, S. Y.
Guttke, C.
Gaj, S.
Pearson, R.
Murphy, J.
van Dijck, W.
Alfonso Piérola, A.
Affiliation
The Christie NHS Foundation Trust, Manchester, UK. University of Manchester, Manchester, UK. CHU de Nice, Hôpital Archet 1, Nice, France. University College London Hospitals NHS Foundation Trust, London, UK. Centre Hospitalier Universitaire de Toulouse, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France. Hématologie et Thérapie Cellulaire, CIC INSERM U1415, Centre Hospitalier Universitaire de Tours, Université de Tours, Tours, France. Fundación Jiménez Díaz University Hospital, START Madrid-FJD, Madrid, Spain. Hospital Clínic de Barcelona, Barcelona, Spain. King's College Hospital, London, UK. Hôpital Saint-Louis (AP-HP), Paris, France. University of Leicester, Leicester, UK. Centre Hospitalier Universitaire de Bordeaux, Hôpital Haut Lévêque, Bordeaux, France. Vall d'Hebron, Barcelona, Spain. Johnson & Johnson, Spring House, Pennsylvania, USA. Johnson & Johnson, Research & Development, Beerse, Belgium. Johnson & Johnson, Research Triangle Park, North Carolina, USA. Johnson & Johnson, High Wycombe, UK. Cancer Center Clinica Universidad de Navarra, Pamplona, Spain.
Description
Date
2025
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All Christie Publications
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Citation
Searle E, Cluzeau T, O'Nions J, Recher C, Gyan E, Morillo D, et al. A phase 1, first-in-human, dose-escalation study of JNJ-74856665 (dihydroorotate dehydrogenase inhibitor) alone or in combination in patients with AML or MDS. British journal of haematology. 2025 Jul 1;207(2):624-30. PubMed PMID: 40598790. Pubmed Central PMCID: PMC12379018. Epub 2025/07/02. eng.
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https://christie.openrepository.com/handle/10541/627449
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