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The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy

Ma, Q.
; 
Zhang, W.
; 
Wu, K.
; 
Shi, L.
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Abstract
KRAS is one of the most mutated genes, driving alternations in metabolic pathways that include enhanced nutrient uptaking, increased glycolysis, elevated glutaminolysis, and heightened synthesis of fatty acids and nucleotides. However, the beyond mechanisms of KRAS-modulated cancer metabolisms remain incompletely understood. In this review, we aim to summarize current knowledge on KRAS-related metabolic alterations in cancer cells and explore the prevalence and significance of KRAS mutation in shaping the tumor microenvironment and influencing epigenetic modification via various molecular activities. Given that cancer cells rely on these metabolic changes to sustain cell growth and survival, targeting these processes may represent a promising therapeutic strategy for KRAS-driven cancers.
Authors
Ma, Q.
Zhang, W.
Wu, K.
Shi, L.
Affiliation
RNA Oncology Group, School of Public Health, Lanzhou University, Lanzhou, 730000, People's Republic of China. Cancer Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, People's Republic of China. wukm_lab@163.com. Cancer Center, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China. wukm_lab@163.com. RNA Oncology Group, School of Public Health, Lanzhou University, Lanzhou, 730000, People's Republic of China. leishi@lzu.edu.cn. Cancer Research UK Manchester Institute, The University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK. leishi@lzu.edu.cn.
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Date
2025
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All Paterson Institute for Cancer Research
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Article
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Ma Q, Zhang W, Wu K, Shi L. The roles of KRAS in cancer metabolism, tumor microenvironment and clinical therapy. Mol Cancer. 2025 Jan 13;24(1):14. PubMed PMID: 39806421. Pubmed Central PMCID: PMC11727292. Epub 2025/01/14. eng.
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https://christie.openrepository.com/handle/10541/628189
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