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Targeting oestrogen receptor signalling in breast cancer therapy

Howell, S. J.
; 
Howell, A.
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Abstract
There has been over 130 years of research into the treatment of breast cancer using approaches that target oestrogen receptor signalling. Here, we summarise the development of the key pillars of such endocrine therapy, namely, oestrogen deprivation, achieved through ovarian suppression and/or aromatase inhibition, and oestrogen receptor blockade, through selective oestrogen receptor modulators, downregulators and novel compounds entering early phase development. The translation of these compounds from advanced to early breast cancer settings is discussed with a focus on the placebo-controlled breast cancer prevention studies to most accurately describe the side effect profiles of the main approaches.
Authors
Howell, S. J.
Howell, A.
Affiliation
Division of Cancer Sciences, University of Manchester, Manchester, UK. sacha.howell@nhs.net. Manchester University NHS Foundation Trust, Manchester, UK. sacha.howell@nhs.net. The Christie NHS Foundation Trust, Manchester, UK. sacha.howell@nhs.net. Division of Cancer Sciences, University of Manchester, Manchester, UK. Manchester University NHS Foundation Trust, Manchester, UK. The Christie NHS Foundation Trust, Manchester, UK.
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Date
2025
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All Christie Publications
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Type
Book chapter
Citation
Howell SJ, Howell A. Targeting Oestrogen Receptor Signalling in Breast Cancer Therapy. Adv Exp Med Biol. 2025;1464:449-74. PubMed PMID: 39821038. Epub 2025/01/17. eng.
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https://christie.openrepository.com/handle/10541/628140
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