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Neoadjuvant treatment in rectal cancer

R, S. B.
; 
Sarin, A.
; 
Aggarwal, S.
; 
Halder, S.
; 
Hukku, S.
; 
Mustafa, T.
; 
Arora, V.
; 
Malik, V. K.
; 
Singh, S.
; 
Rao, G. V.
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Abstract
A major advance in rectal cancer was the evidence supporting short-course radiotherapy and long-course chemoradiotherapy. Both have been shown to improve local outcomes. Total neoadjuvant therapy (TNT) is the new kid on the block that provides further benefit of improving local responses as well as reducing systemic relapses, thus increasing overall survival. Details of the four key TNT trials are discussed. They pave the way for nonoperative management for patients who achieve clinical complete responses.
Authors
R, S. B.
Sarin, A.
Aggarwal, S.
Halder, S.
Hukku, S.
Mustafa, T.
Arora, V.
Malik, V. K.
Singh, S.
Rao, G. V.
Saklani, A.
Bhojwani, R.
Rawat, S.
Selvasekar, C.
Parikh, P. M.
Affiliation
Department of Medical Oncology, Apollo Cancer Institutes, Hyderabad, Telangana, India. Department of Medical Oncology, Sir Ganga Ram Hospital, New Delhi, India. Department of Radiation Oncology, Sir Ganga Ram Hospital, New Delhi, India. Department of Radiation Oncology, BLK Max Hospital, New Delhi, India. Department of Colo Rectal Surgery, Sir Ganga Ram Hospital, New Delhi, India. Department of Laparoscopic Surgery, Sir Ganga Ram Hospital, New Delhi, India. Department of GI Oncosurgery, RGCI, New Delhi, India. Department of Gastrointestinal and Minimally Invasive Surgery, Asian Institute of Gastroenterology, Hyderabad, Telangana, India. Department of Colorectal Surgery, Tata Memorial Hospital, Mumbai, Maharashtra, India. Department of Surgical Gastroenterology, Santokba Durlabhji Memorial Hospital, Jaipur, Rajasthan, India. Department of Surgical Gastroenterology, SGRH, New Delhi, India. Clinical Services and Specialist Surgery, The Christie NHS Foundation Trust, Manchester, United Kingdom. Department of Clinical Hematology, Sri Ram Cancer Center, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India.
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2024
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All Christie Publications
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Citation
R SB, Sarin A, Aggarwal S, Halder S, Hukku S, Mustafa T, et al. Neoadjuvant Treatment in Rectal Cancer. South Asian J Cancer. 2024 Oct;13(4):274-80. PubMed PMID: 40060347. Pubmed Central PMCID: PMC11888809. Epub 2025/03/10. eng.
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https://christie.openrepository.com/handle/10541/627923
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