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Obesity management for patients with coronary artery disease and heart failure

Syed, A. A.
; 
Adam, S.
; 
Miller, C. A.
; 
Alkhaffaf, B.
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Abstract
Obesity is causally linked to heart disease directly by triggering various adverse pathophysiological changes and indirectly through convergent risk factors such as type 2 diabetes, hypertension, dyslipidemia, and sleep disorder. Weight reduction is an important intervention for obesity-related cardiomyopathy, and antiobesity medications that target both obesity and heart failure (HF), particularly sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide 1 receptor agonists, have a role in treatment. Bariatric surgery offers a viable treatment option for patients with severe obesity associated with coronary artery disease and HF but requires careful patient selection, preoperative optimization, choice of procedure, and postoperative management to minimize risks.
Authors
Syed, A. A.
Adam, S.
Miller, C. A.
Alkhaffaf, B.
Affiliation
Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK; Department of Diabetes, Endocrinology & Obesity Medicine, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK. Electronic address: akheel.syed@manchester.ac.uk. Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK; Department of Diabetes & Endocrinology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK. Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK; BHF (British Heart Foundation) Manchester Centre for Heart and Lung Magnetic Resonance Research, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester M23 9LT, UK. Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester M13 9PL, UK; Department of Oesophago-Gastric & Bariatric Surgery, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Stott Lane, Salford M6 8HD, UK.
Description
Date
2025
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All Christie Publications
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Article
Citation
Syed AA, Adam S, Miller CA, Alkhaffaf B. Obesity management for patients with coronary artery disease and heart failure. Heart failure clinics. 2025 Apr;21(2):257-71. PubMed PMID: 40107803. Epub 2025/03/20. eng.
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https://christie.openrepository.com/handle/10541/627938
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