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DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors
Cardoso, A. Buck, M. D. Frederico, B. Chakravarty, P. Schulz, O. Lim, K. H. J. Piot, C. da Costa, M. P. Giampazolias, E. Gasparrini, F.
Cardoso, A.
Buck, M. D.
Frederico, B.
Chakravarty, P.
Schulz, O.
Lim, K. H. J.
Piot, C.
da Costa, M. P.
Giampazolias, E.
Gasparrini, F.
Abstract
Conventional dendritic cells (cDCs) are sentinel cells that play a crucial role in both innate and adaptive immune responses. cDCs originate from a progenitor (pre-cDC) in the bone marrow (BM) that travels via the blood to seed peripheral tissues before locally differentiating into functional cDC1 and cDC2 cells, as part of a process known as cDCpoiesis. How cDCpoiesis is regulated and whether this affects the output of cDCs is poorly understood. In this study, we show that DNGR-1, an innate immune receptor expressed by cDC progenitors and type 1 cDCs, can regulate cDCpoiesis in mice. In a competitive chimera setting, cDC progenitors lacking DNGR-1 exhibit increased proliferation and tissue migratory potential. Compared with their WT counterparts, DNGR-1-deficient cDC progenitor cells display superior colonization of peripheral tissues but an altered distribution. These findings suggest that cDCpoiesis can be regulated in part by precursor cell-intrinsic processes driven by signals from innate immune receptors such as DNGR-1 that may respond to alterations in the BM milieu.
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Date
2025
Publisher
Collections
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Article
Citation
Cardoso A, Buck MD, Frederico B, Chakravarty P, Schulz O, Lim KHJ, et al. DNGR-1 regulates proliferation and migration of bone marrow dendritic cell progenitors. JOURNAL OF EXPERIMENTAL MEDICINE. 2025 MAY 13;222(8). PubMed PMID: WOS:001487304900001. English.