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Recurrent and refractory ewing sarcoma phase I/II trials: current perspective from the Euro-Ewing Consortium

Juan Ribelles, A.
; 
Felix, A.
; 
Benavent, N.
; 
Escrivá-Fernández, J.
; 
Brahmi, M.
; 
Gaspar, N.
; 
Gatz, S. A.
; 
Grünewald, T. G.
; 
Linder-Stragliotto, C.
; 
Palmerini, E.
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Abstract
PURPOSE: Updated analysis of phase I/II trials in recurrent/refractory (R/R) Ewing sarcoma (EwS) over the past 11 years. METHODS: A systematic review was performed to identify phase I/II trials for R/R EwS in three databases (WHO, US National Library of Medicine, and European Clinical Trials Database) and/or published in PubMed/ASCO/European Society for Medical Oncology websites from 2014 to 2024. The search criteria included EwS OR bone sarcoma OR sarcoma AND Phase-I OR Phase-II. Eligibility and data extraction were performed independently by three reviewers, with priority given to trials with EwS specified data. Trials were categorized by therapeutic intervention, including targeted therapies, immunotherapy, chemotherapy, and combined therapies. RESULTS: One hundred eight trials met inclusion criteria, predominantly academic (70%) and multicenter (81.5%), with significant US and European collaboration. Trial designs were mainly single-arm, with an increase in multiarm trials in the recent years and increased focus on the pediatric population. Trial modalities emphasized targeted therapies with tyrosine kinase, poly-ADP ribose polymerase, EWSR1
Authors
Juan Ribelles, A.
Felix, A.
Benavent, N.
Escrivá-Fernández, J.
Brahmi, M.
Gaspar, N.
Gatz, S. A.
Grünewald, T. G.
Linder-Stragliotto, C.
Palmerini, E.
Pantziarka, P.
Strauss, S.
Surdez, D.
Berlanga, P.
McCabe, M. G.
Affiliation
Pediatric Oncology and Hematology Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain. Department of Pediatrics, Children Hematology and Oncology Unit, University Hospital of Fort-de France, Martinique, France. EpiCliV Research Unit, University of the French West Indies, University Hospital of Fort-de France, Martinique, France. Pediatric Oncology and Hematology Unit, La Fe Health Research Institute, Valencia, Spain. Department of Medical Oncology, Centre Léon Bérard, Lyon, France. Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Campus, Université Paris-Saclay, Villejuif, France. Department of Cancer and Genomic Sciences, School of Medical Sciences, College of Medicine and Health, University of Birmingham, Birmingham, United Kingdom. Department of Paediatric Oncology, Women's and Children's NHS Foundation Trust, Steelhouse Ln, Birmingham, United Kingdom. Hopp-Children's Cancer Center (KiTZ) Heidelberg, Heidelberg, Germany. Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. National Center for Tumor Diseases (NCT), NCT Heidelberg, a Partnership Between DKFZ and Heidelberg University Hospital, Heidelberg, Germany. Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL. Anticancer Fund, Meise, Belgium. George Pantziarka TP53 Trust, Kingston, United Kingdom. UCL Cancer Institute, University College London, London, United Kingdom. Balgrist University Hospital, Faculty of Medicine, University of Zurich (UZH), Zurich, Switzerland. Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. The Christie NHS Foundation Trust, Manchester, United Kingdom.
Description
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2025
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All Christie Publications
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Article
Citation
Juan Ribelles A, Felix A, Benavent N, Escrivá-Fernández J, Brahmi M, Gaspar N, et al. Recurrent and Refractory Ewing Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium. JCO Precis Oncol. 2025 Sep;9:e2500377. PubMed PMID: 40971749. Epub 2025/09/19. eng.
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https://christie.openrepository.com/handle/10541/628056
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