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Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database

Zalevskaja, K.
; 
Ojala, K.
; 
Petrov, A.
; 
Haupt, S.
; 
Sunde, L.
; 
Bernstein
; 
Jenkins, M. A.
; 
Aretz, S.
; 
Nielsen, M.
; 
Capella, G.
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Abstract
This first prospective observational study evaluates the impact of extended versus segmental colorectal surgery on the risk of metachronous colorectal cancer (CRC) in patients with Lynch syndrome, analyzing data from the Prospective Lynch Syndrome Database version 5. Extended resection significantly reduced the risk of metachronous CRC in path_MLH1, path_MSH2, and path_MSH6 carriers compared to segmental resection.
Authors
Zalevskaja, K.
Ojala, K.
Petrov, A.
Haupt, S.
Sunde, L.
Bernstein
Jenkins, M. A.
Aretz, S.
Nielsen, M.
Capella, G.
Balaguer, F.
Evans, D. G.
Burn, J.
Holinski-Feder, E.
Bertario, L.
Bonanni, B.
Lindblom, A.
Levi, Z.
Macrae, F.
Winship
Plazzer, J. P.
Sijmons, R.
Laghi, L.
Della Valle, A.
Heinimann, K.
Debniak, T.
Fruscio, R.
Lopez-Koestner, F.
Alvarez-Valenzuela, K.
Katz, L. H.
Laish
Vainer, E.
Vaccaro, C.
Carraro, D. M.
Monahan, K.
Half, E.
Stakelum, A.
Winter, D.
Kennelly, R.
Gluck, N.
Sheth, H.
Abu-Freha, N.
Greenblatt, M.
Rossi, B. M.
Bohorquez, M.
Cavestro, G. M.
Lino-Silva, L. S.
Horisberger, K.
Tibiletti, M. G.
do, N.
Thomas, H.
Rossi, N. T.
da Silva, L. A.
Zarand, A.
Ruiz-Banobre, J.
Heuveline
Lindberg, L. J.
Gögenur
Hopper, J. L.
Win, A. K.
Haile, R. W.
Lindor, N.
Gallinger, S.
Le Marchand, L.
Newcomb, P. A.
Figueiredo, J.
Buchanan, D. D.
Thibodeau, S. N.
Doeberitz, M. V. K.
Loeffler, M.
Rahner, N.
Schröck, E.
Steinke, L.
Schmiegel, W.
Vangala, D.
Perne, C.
Hüneburg, R.
Redler, S.
Büttner, R.
Weitz, J.
Pineda, M.
Duenas, N.
Vidal, J. B.
Moreira, L.
Sanchez, A.
Castillo-Iturra, J.
Hovig, E.
Green, K.
Lalloo, F.
Hill, J.
Crosbie, E.
Mints, M.
Goldberg, Y.
Tjandra, D.
ten Broeke, S. W.
Kariv, R.
Rosner, G.
Jain, A.
Shah, P.
Shah, M.
Neffa, F.
Esperon, P.
Pavicic, W.
Torrezan, G. T.
Bassaneze, T.
Martin, C. A.
Pylvänäinen, K.
Moeslein, G.
Lepistoe, A.
Mecklin, J. P.
Renkonen-Sinisalo, L.
Sampson, J. R.
Valentin, M. D.
Moller, P.
Seppälä, T. T.
Affiliation
Univ Helsinki, Res Programs Unit, Appl Tumor Genom Res Program, Helsinki, Finland Mikkeli Cent Hosp, Dept Surg, Porrassalmenkatu 35-37, Mikkeli 50100, Finland Helsinki Univ Hosp, Dept Abdominal Surg, Helsinki, Finland Tampere Univ, Fac Med & Hlth Technol, Tampere, Finland Tampere Univ Hosp, Tays Canc Ctr, Tampere, Finland Heidelberg Univ, Interdisciplinary Ctr Sci Comp IWR, Engn Math & Comp Lab EMCL, Heidelberg, Germany Heidelberg Inst Theoret Studies HITS, Data Min & Uncertainty Quantificat DMQ, Heidelberg, Germany Aalborg Univ Hosp, Dept Clin Genet, Aalborg, Denmark Aalborg Univ, Dept Clin Med, Gistrup, Denmark Aalborg Univ, Aalborg Univ Hosp, Dept Qual & Coherence, Aalborg, Denmark Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Parkville, Vic, Australia Univ Bonn, Univ Hosp Bonn, Natl Ctr Hereditary Tumor Syndromes, Inst Human Genet,Med Fac, Bonn, Germany Leids Univ, Med Ctr, Dept Clin Genet, Leiden, Netherlands Inst Catala Oncol IDIBELL, Hereditary Canc Program, Barcelona, Spain Hosp Clin Barcelona, Dept Gastroenterol, Barcelona, Spain Manchester Univ NHS Fdn Trust, Manchester Ctr Genom Med, Manchester, Lancs, England Newcastle Univ, Fac Med Sci, Newcastle Upon Tyne, Tyne & Wear, England Klinikum Univ Munchen, Med Klin & Poliklin 4, Campus Innenstadt, Munich, Germany Ctr Med Genet, Munich, Germany European Inst Oncol IRCCS, Div Canc Prevent & Genet, Milan, Italy Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden Dept Rabin Med Ctr, Serv High Risk GI Canc Gastroenterol, Petah Tiqwa, Israel Royal Melbourne Hosp, Colorectal Med & Genet, Melbourne, Vic, Australia Univ Melbourne, Dept Med, Melbourne, Vic, Australia Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands IRCCS Humanitas Res Hosp, Lab Mol Gastroenterol, Rozzano, Italy Univ Parma, Dept Med & Surg, Parma, Italy Hosp Fuerzas Armadas, Grp Colaborat Uruguayo, Invest Afecc Oncol Hereditarias, Montevideo, Uruguay Univ Hosp Basel, Inst Med Genet & Pathol, Med Genet, Basel, Switzerland Int Hereditary Canc Ctr, Dept Genet & Pathol, Szczecin, Poland Univ Milano Bicocca, AO San Gerardo, Clin Obstet & Gynecol, Dept Med & Surg, Monza, Italy Clin Univ Andes, Santiago, Chile Programa Canc Heredo Familiar, Santiago, Chile Hebrew Univ Jerusalem, Hadassah Med Ctr, Fac Med, Dept Gastroenterol, Jerusalem, Israel Hadassah Med Ctr, Jerusalem, Israel Hosp Italiano Buenos Aires, Hereditary Canc Program PROCANHE, Buenos Aires, DF, Argentina AC Camargo Canc Ctr, Clin & Funct Genom Grp, Sao Paulo, Brazil St Marks Hosp, Lynch Syndrome & Family Canc Clin, London, England Rambam Hlth Care Campus, Dept Gastroenterol, Gastrointestinal Canc Prevent Unit, Haifa, Israel St Vincents Univ Hosp, Dublin, Ireland Tel Aviv Sourasky Med Ctr, Dept Gastroenterol, Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel Inst Human Genet, Fdn Res Genet & Endocrinol, Ahmadabad, Gujarat, India Ben Gurion Univ Negev, Soroka Univ, Med Ctr, Beer Sheva, Israel Univ Vermont, Larner Coll Med, Burlington, VT USA Hosp Sirio Libanes, Sao Paulo, Brazil Univ Tolima, Tolima, Colombia Univ Vita Salute San Raffaele, IRCCS San Raffaele Sci Inst, Div Expt Oncol, Gastroenterol & Gastrointestinal Endoscopy Unit, Milan, Italy Inst Nacl Cancerol, Surg Pathol, Mexico City, DF, Mexico Univ Med Mainz, Dept Surg, Mainz, Germany Univ Insubria, Ctr Ric Tumori Eredofamiliari, Osped Circolo ASST Settelaghi, Varese, Italy Univ Fed Bahia, Salvador, Brazil Imperial Coll London, St Marks Hosp, Dept Surg & Canc, London, England Sanatorio Allende, Fdn El Progreso Med, Cordoba, Argentina Univ Pernambuco, Hosp Univ Oswaldo Cruz, Recife, PE, Brazil SEQUIPE, Recife, PE, Brazil Semmelweis Univ, Dept Surg 1, Budapest, Hungary Univ Clin Hosp Santiago Compostela, Dept Med Oncol, Santiago De Compostela, Spain Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain Copenhagen Univ Hosp, Amager & Hvidovre Hosp, Danish HNPCC Register, Gastrounit, Hvidovre, Denmark Zealand Univ Hosp, Surg Sci Ctr, Dept Surg, Koge, Denmark Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Parkville, Vic, Australia Stanford Univ, Stanford Canc Inst, Div Oncol, Dept Med, Stanford, CA 94305 USA Mayo Clin Arizona, Dept Hlth Sci Res, Phoenix, AZ USA Univ Toronto, Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA Univ Melbourne, Dept Clin Pathol, Colorectal Oncogen Grp, Parkville, Vic, Australia Univ Melbourne, Victorian Comprehens Canc Ctr, Ctr Canc Res, Parkville, Vic, Australia Royal Melbourne Hosp, Genom Med & Family Canc Clin, Parkville, Vic, Australia Mayo Clin, Dept Lab Med & Pathol, Rochester, NY USA Univ Hosp Heidelberg, Inst Pathol, Dept Appl Tumour Biol, Heidelberg, Germany German Canc Res Ctr, Cooperat Unit Appl Tumour Biol, Heidelberg, Germany Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany Heinrich Heine Univ Dusseldorf, Inst Human Genet, Fac Med, Dusseldorf, Germany Heinrich Heine Univ Dusseldorf, Univ Hosp Dusseldorf, Dusseldorf, Germany Partner Site Dresden, Natl Ctr Tumor Dis NCT, Dresden, Germany German Canc Consortium DKTK Dresden, Heidelberg, Germany German Canc Res Ctr DKFZ Heidelberg, Heidelberg, Germany Tech Univ Dresden, Fac Med, Inst Clin Genet, Dresden, Germany Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Dresden, Germany Tech Univ Dresden, Fac Med, Hereditary Canc Syndrome Ctr Dresden, Dresden, Germany MGZ Med Genet Ctr, Munich, Germany Ruhr Univ Bochum, Knappschaftskrankenhaus, Dept Med, Bochum, Germany Univ Hosp Bonn, Dept Internal Med, Bonn, Germany Fac Med, Inst Pathol, Cologne, Germany Univ Hosp Cologne, Cologne, Germany Tech Univ Dresden, Dresden, Germany Norwegian Radium Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway Univ Oslo, Dept Informat, Ctr Bioinformat, Oslo, Norway Cent Manchester Univ Hosp NHS Fdn Trust, Dept Surg, Manchester, Lancs, England Univ Manchester, Manchester, Lancs, England Manchester Univ NHS Fdn Trust, Gynaecol Oncol Res Grp, Manchester, Lancs, England Univ Manchester, Div Canc Sci, Manchester, Lancs, England Karolinska Univ Hosp, Karolinska Inst, Dept Womens & Childrens Hlth, Div Obstet & Gynaecol, Stockholm, Sweden Rabin Med Ctr Beilinson Hosp, Raphael Recanati Genet Inst, Head Adult Genet Serv, Petah Tiqwa, Israel Gastrol Hosp, Ahmadabad, Gujarat, India Zydus Canc Ctr, Ahmadabad, Gujarat, India Hosp Italiano Buenos Aires, CONICET IU, Inst Med Traslac & Ingn Biomed IMTIB, Buenos Aires, DF, Argentina Hosp Privado Univ Cordoba, Cordoba, Argentina Wellbeing Serv Cent Finland, Dept Educ & Sci, Jyvaskyla, Finland Univ Witten Herdecke, Ev Bethesda Khs Duisburg, Surg Ctr Hereditary Tumors, Herdecke, Germany Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland Wellbeing Serv Cent Finland, Dept Educ & Res, Jyvaskyla, Finland Cardiff Univ, Sch Med, Div Canc & Genet, Cardiff, Wales
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2025
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All Paterson Institute for Cancer Research
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Zalevskaja K, Ojala K, Petrov A, Haupt S, Sunde L, Bernstein, et al. Metachronous colorectal cancer risks after extended or segmental resection in MLH1, MSH2, and MSH6 Lynch syndrome: multicentre study from the Prospective Lynch Syndrome Database. BJS - BRITISH JOURNAL OF SURGERY. 2025 APR;112(4). PubMed PMID: WOS:001466497900001. English.
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https://christie.openrepository.com/handle/10541/627895
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