Thumbnail Image
Item

The evolution of targeted intra operative radiotherapy in early breast cancer

Das, A.
; 
Abdulkarim, K.
; 
Banerjee, S.
; 
Kurmude, R.
; 
Tan, J. K.
; 
Prusty, L.
; 
Mahajan, I.
; 
Ghose, A.
; 
Tiwari, A.
; 
Kassamali, A.
... show 5 more
Citations
Google Scholar:
Lookup
Altmetric:
Abstract
Targeted intraoperative radiotherapy (IORT) delivers a single dose of radiation to a fresh tumour bed immediately after lumpectomy, commonly used to treat early breast cancer (EBC). It is delivered during the same sitting, with improved patient compliance and better sparing of adjacent healthy tissue, compared to conventional adjuvant radiotherapy to the whole breast. The recently published 12-year results (median follow up of 8.6 years) of the TARGIT-A trial offers reliable conclusions, of comparable oncological outcomes with a reduced toxicity profile supporting IORT as a replacement for whole breast external beam radiotherapy (EBRT) for suitable patients with EBC. Reduced need of multiple hospital visits is an added logistic advantage which makes IORT a cost-effective, less painful and cosmetically favourable alternative to standard EBRT, now included in several international guidelines with growing popularity among clinicians worldwide.
Authors
Das, A.
Abdulkarim, K.
Banerjee, S.
Kurmude, R.
Tan, J. K.
Prusty, L.
Mahajan, I.
Ghose, A.
Tiwari, A.
Kassamali, A.
Hasanova, M.
Chapagain, P.
Linares, C. A.
Vaidya, J. S.
Boussios, S.
Affiliation
Tata Medical Center - Cancer Hospital and Research Center, Kolkata, India. Department of General Surgery, Medway NHS Foundation Trust, Kent, UK. Cancer Centre at Guy's, Guy's and St. Thomas' NHS Foundation Trust, London, UK. Department of Internal Medicine, Bethlehem Gesundheitszentrum Stolberg (Rhld.) gGmbH, Stolberg, Germany. Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Department of Clinical Oncology, The Christie NHS Foundation Trust, Manchester, UK. British Oncology Network for Undergraduate Societies, London, UK. Department of Breast Surgery, Lincoln County Hospital, United Lincolnshire Hospitals NHS Trust, Lincoln, UK. The Mammary Fold, Association of Breast Surgery, London, UK. Queen's Centre for Oncology and Haematology, Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust, Cottingham, UK. Barts Cancer Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK. aruni.ghose1@gmail.com. Barts Cancer Institute, Cancer Research UK City of London Centre, Queen Mary University of London, London, UK. aruni.ghose1@gmail.com. Health Systems and Treatment Optimisation Network, European Cancer Organisation, Brussels, Belgium. aruni.ghose1@gmail.com. United Kingdom and Ireland Global Cancer Network, Manchester, UK. aruni.ghose1@gmail.com. Oncology Council, Royal Society of Medicine, London, UK. aruni.ghose1@gmail.com. Department of Surgery, Princess Alexandra Hospital NHS Trust, Harlow, UK. Barts Cancer Centre, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK. Division of Biosciences, University College London, London, UK. Oncology Service, Broomsfield Hospital, Mid and South Essex NHS Foundation Trust, Chelmsford, UK. Department of Oncology, Barking Havering and Redbridge University Hospitals NHS Trust, Romford, UK. Surgical Interventional Trials Unit, Division of Surgery and Interventional Science, University College London, London, UK. Breast Unit, King Edward VII Hospital, London, UK. Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece. Department of Medical Oncology, Ioannina University Hospital, Ioannina, Greece. AELIA Organization, 9th Km Thessaloniki-Thermi, 57001, Thessaloniki, Greece. Faculty of Life Sciences and Medicine, School of Cancer and Pharmaceutical Sciences, King's College London, Strand, London, UK. Faculty of Medicine, Health, and Social Care, Canterbury Christ Church University, Canterbury, UK.
Description
Date
2025
Publisher
Collections
All Christie Publications
Show all metadata
Files
Thumbnail Image
Found from Unpaywall
Adobe PDF, 1.9 MB
Keywords
Type
Article
Citation
Das A, Abdulkarim K, Banerjee S, Kurmude R, Tan JK, Prusty L, et al. The evolution of targeted intra operative radiotherapy in early breast cancer. J Cancer Res Clin Oncol. 2025 Sep 10;151(9):249. PubMed PMID: 40928546. Pubmed Central PMCID: PMC12423025. Epub 2025/09/10. eng.
Journal Title
Journal ISSN
Volume Title
URI
https://christie.openrepository.com/handle/10541/628165
Embedded videos