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    Intra-tumoral heterogeneity of tumour potential doubling times (Tpot) in colorectal cancer.

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    Authors
    Wilson, Malcolm S
    West, Catharine M L
    Wilson, G D
    Roberts, Stephen A
    James, Roger D
    Schofield, Philip F
    Affiliation
    Clinical Research Department, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1993-09
    
    Metadata
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    Abstract
    Intra-tumoural heterogeneity of proliferation has been assessed by taking multiple biopsies from 30 colorectal cancers. Following in vivo IUDR labelling, dual parameter flow cytometry was used to measure tumour DNA index (DI) and labelling index (LI) and to derive DNA synthesis time (Ts) and potential doubling time (Tpot). Heterogeneity was seen for all parameters under investigation. Overall coefficients of variation (CV) and logarithmic transformation of Ts and Tpot (due to their non-gaussian distributions) indicate that LI (CV 25%) was the most variable parameter. Intra-tumoral heterogeneity in Tpot (lnTpot CV = 22%) was less than inter-individual variation (CV = 63%), suggesting that this variation should not be a limitation to the possible usefulness of this technique as an independent prognostic indicator. Correlations of Tpot values were examined between the shortest, the median and the value for a pooled homogenate sample from a single tumour. Using an homogenate, it was possible to accurately predict classification of tumour Tpot values as being below the median ('fast tumours') in 15 of 19 cases (79%). The data suggest that assaying an homogenate may allow a more rapid analysis of a multiply sampled tumour.
    Citation
    Intra-tumoral heterogeneity of tumour potential doubling times (Tpot) in colorectal cancer. 1993, 68 (3):501-6 Br. J. Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/99951
    PubMed ID
    8353040
    Type
    Article
    Language
    en
    ISSN
    0007-0920
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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