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    p53 overexpression as a marker of malignancy in gastric biopsies.

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    Authors
    Starzynska, T
    Marsh, P J
    Stern, Peter L
    Affiliation
    Department of Gastroenterology, Medical Pomeranian Academy, Szczecin, Poland.
    Issue Date
    1993-12
    
    Metadata
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    Abstract
    Inactivation of the p53 tumour-suppressor gene is the commonest genetic abnormality in human cancers. This results in a conformational change in the p53 protein, and a consequent prolongation in its half-life; thereby permitting the identification of p53 immunoreactivity in malignant cells. Such reactivity is observed in up to 57% of gastric carcinomas, and is a proven indicator of poor prognosis. We have investigated the use of p53 immunohistochemistry in the diagnosis of malignancy in pre-operative gastric biopsy specimens. Using a three-stage immunoperoxidase technique, p53 expression was examined in 117 gastric biopsies obtained during flexible upper gastrointestinal endoscopy: 80 of these biopsies were from known gastric carcinomas, 20 from benign gastric disorders and 17 from normal gastric mucosa. Of the gastric cancers 40% (n = 32) exhibited overexpression of p53. No reactivity was observed in any of the biopsies of gastric ulcers, polyps or normal mucosa. The expression of p53 by gastric carcinomas improved the diagnostic accuracy of conventional histopathology from 86% to 92.5%; with 5% of biopsies incorrectly diagnosed and 2.5% of an equivocal appearance. These results demonstrate that the detection of p53 is a highly specific marker of gastric malignancy, and that such a technique can easily be performed on biopsies obtained at endoscopy.
    Citation
    p53 overexpression as a marker of malignancy in gastric biopsies. 1993, 2 (6):321-4 Surg Oncol
    Journal
    Surgical Oncology
    URI
    http://hdl.handle.net/10541/99948
    DOI
    10.1016/0960-7404(93)90062-4
    PubMed ID
    8130938
    Type
    Article
    Language
    en
    ISSN
    0960-7404
    ae974a485f413a2113503eed53cd6c53
    10.1016/0960-7404(93)90062-4
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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