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    Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer.

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    Authors
    Van Hoef, M E
    Knox, W F
    Dhesi, S S
    Howell, Anthony
    Schor, Ana M
    Affiliation
    Department of Medical Oncology, Paterson Institute for Cancer Research, Manchester, U.K.
    Issue Date
    1993
    
    Metadata
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    Abstract
    The association between tumour vascularity and relapse was examined in 93 patients with lymph node negative (LNN) invasive breast cancer. Factor VIII-related antibody was used to stain the microvessels. Vascularity was defined by the number of vessels per field counted in the area of highest vascular density at 100 x magnification. These vascular counts were divided into three groups of vascular density (group I: < 67, group 2: 68-100, group 3: > 101 vessels/field). Cross-tabulation analysis revealed a significant relationship between vascular density and tumour grade (P = 0.027). No association was found between vascularity and tumour size, tumour type, age or menopausal status. Survival analysis showed no association between vascularity and relapse-free (P = 0.92) or overall survival (P = 0.99). Significant associations between tumour grade and relapse-free (P = 0.0048) and overall survival (P = 0.0064) and between tumour size at the cut off of 15 mm diameter and relapse-free (P = 0.0097) and overall survival (P = 0.0271) were found. When grade was taken into account the effect of tumour size became non-significant (P = 0.059). Our results suggest that assessment of vascularity is not an independent prognostic factor in LNN invasive breast cancer.
    Citation
    Assessment of tumour vascularity as a prognostic factor in lymph node negative invasive breast cancer. 1993, 29A (8):1141-5 Eur. J. Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/99921
    DOI
    10.1016/S0959-8049(05)80304-1
    PubMed ID
    8390846
    Type
    Article
    Language
    en
    ISSN
    0959-8049
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0959-8049(05)80304-1
    Scopus Count
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    All Christie Publications
    All Paterson Institute for Cancer Research

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