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    Effect of irradiation treatment on gonadal function in men treated for germ cell cancer.

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    Authors
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1993
    
    Metadata
    Show full item record
    Abstract
    Irradiation may have a profound effect on reproductive function. The schedule of the delivered irradiation (total dose, number of fractions and duration) is an important determinant of the radiobiological effect on the tissues involved and varies between different tissues and organs. Direct irradiation to the testis will, in lower doses, affect the germinal epithelium: doses of irradiation greater than 0.35 Gy cause aspermia which may be reversible. The time taken for recovery increases with larger doses, however, with doses in excess of 2 Gy aspermia may be permanent. At high radiation doses (> 20 Gy) Leydig cell function will also be affected.
    Citation
    Effect of irradiation treatment on gonadal function in men treated for germ cell cancer. 1993, 23 (1):148-51; discussion 152 Eur. Urol.
    Journal
    European Urology
    URI
    http://hdl.handle.net/10541/99808
    PubMed ID
    8386642
    Type
    Article
    Language
    en
    ISSN
    0302-2838
    Collections
    All Christie Publications

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