Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma.
dc.contributor.author | Goyns, M H | |
dc.contributor.author | Hammond, David W | |
dc.contributor.author | Harrison, Christine J | |
dc.contributor.author | Menasce, Lia P | |
dc.contributor.author | Ross, F M | |
dc.contributor.author | Hancock, Barry W | |
dc.date.accessioned | 2010-05-25T11:58:38Z | |
dc.date.available | 2010-05-25T11:58:38Z | |
dc.date.issued | 1993-06 | |
dc.identifier.citation | Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma. 1993, 7 (6):848-52 Leukemia | en |
dc.identifier.issn | 0887-6924 | |
dc.identifier.pmid | 8501979 | |
dc.identifier.uri | http://hdl.handle.net/10541/99804 | |
dc.description.abstract | It has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28. | |
dc.language.iso | en | en |
dc.subject.mesh | Aneuploidy | |
dc.subject.mesh | Chromosome Aberrations | |
dc.subject.mesh | Chromosome Disorders | |
dc.subject.mesh | Chromosome Mapping | |
dc.subject.mesh | Female | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Lymphoma, Non-Hodgkin | |
dc.subject.mesh | Male | |
dc.subject.mesh | X Chromosome | |
dc.title | Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma. | en |
dc.type | Article | en |
dc.contributor.department | Department of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, UK. | en |
dc.identifier.journal | Leukemia | en |
html.description.abstract | It has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28. |