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dc.contributor.authorGoyns, M H
dc.contributor.authorHammond, David W
dc.contributor.authorHarrison, Christine J
dc.contributor.authorMenasce, Lia P
dc.contributor.authorRoss, F M
dc.contributor.authorHancock, Barry W
dc.date.accessioned2010-05-25T11:58:38Z
dc.date.available2010-05-25T11:58:38Z
dc.date.issued1993-06
dc.identifier.citationStructural abnormalities of the X chromosome in non-Hodgkin's lymphoma. 1993, 7 (6):848-52 Leukemiaen
dc.identifier.issn0887-6924
dc.identifier.pmid8501979
dc.identifier.urihttp://hdl.handle.net/10541/99804
dc.description.abstractIt has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.
dc.language.isoenen
dc.subject.meshAneuploidy
dc.subject.meshChromosome Aberrations
dc.subject.meshChromosome Disorders
dc.subject.meshChromosome Mapping
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLymphoma, Non-Hodgkin
dc.subject.meshMale
dc.subject.meshX Chromosome
dc.titleStructural abnormalities of the X chromosome in non-Hodgkin's lymphoma.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, UK.en
dc.identifier.journalLeukemiaen
html.description.abstractIt has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.


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