Structural abnormalities of the X chromosome in non-Hodgkin's lymphoma.
AffiliationDepartment of Clinical Oncology, Royal Hallamshire Hospital, Sheffield, UK.
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AbstractIt has recently been reported that additional X chromosomes occur in over 30% of B-cell non-Hodgkin's lymphomas (NHL), and that monosomy of the X chromosome occurs in 38% of female patients with T-cell leukaemia or lymphoma. These observations have suggested a possible role for the X chromosome in the evolution of NHL. We have now examined 280 cases of NHL, and have identified 19 examples of structurally altered X chromosomes in the malignant cells from 17 of these cases. These abnormalities were mainly characterized by either a translocation involving Xp22, or a translocation/deletion involving Xq28. The relevance of these observations is discussed with respect to other published reports, and together they suggest that lymphoma-associated oncogenes may exist on the X chromosome at bands p22 or q28.
CitationStructural abnormalities of the X chromosome in non-Hodgkin's lymphoma. 1993, 7 (6):848-52 Leukemia
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