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    The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites.

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    Authors
    Pitt, M A
    Roberts, I S
    Agbamu, D A
    Eyden, Brian P
    Affiliation
    Department of Histopathology, Christie Hospital, Manchester, UK.
    Issue Date
    1993-08
    
    Metadata
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    Abstract
    The morphology, immunophenotype and ultrastructure of atypical multinucleated stromal cells in 37 specimens from different anatomical sites were compared. Overall, cellular morphology was similar between sites but nuclear features, immunophenotype and ultrastructure varied and reflected that of adjacent normal mononuclear stromal cells. It is concluded that the atypical multinucleated stromal cells represent a reactive change in the indigenous stromal cells. In all the cases mast cells were seen as a prominent component of the inflammatory infiltrate and many of them were intimately related to the atypical stromal cells. It is suggested that reactive stromal cell changes may relate to an interaction with mast cells.
    Citation
    The nature of atypical multinucleated stromal cells: a study of 37 cases from different sites. 1993, 23 (2):137-45 Histopathology
    Journal
    Histopathology
    URI
    http://hdl.handle.net/10541/99797
    DOI
    10.1111/j.1365-2559.1993.tb00471.x
    PubMed ID
    8406385
    Type
    Article
    Language
    en
    ISSN
    0309-0167
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2559.1993.tb00471.x
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