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dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorHarris, Martin
dc.contributor.authorEyden, Brian P
dc.contributor.authorHowell, S
dc.contributor.authorWells, S
dc.contributor.authorMainwaring, A R
dc.date.accessioned2010-05-25T10:38:15Z
dc.date.available2010-05-25T10:38:15Z
dc.date.issued1993-03
dc.identifier.citationChondroid syringoma with hyaline cell change. 1993, 22 (3):235-45 Histopathologyen
dc.identifier.issn0309-0167
dc.identifier.pmid7684353
dc.identifier.doi10.1111/j.1365-2559.1993.tb00113.x
dc.identifier.urihttp://hdl.handle.net/10541/99793
dc.description.abstractFour cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.
dc.language.isoenen
dc.subject.meshActins
dc.subject.meshAdenoma, Sweat Gland
dc.subject.meshAdult
dc.subject.meshCarcinoembryonic Antigen
dc.subject.meshCartilage
dc.subject.meshCartilage Diseases
dc.subject.meshFemale
dc.subject.meshGlial Fibrillary Acidic Protein
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshIntermediate Filaments
dc.subject.meshKeratins
dc.subject.meshMale
dc.subject.meshMicroscopy, Electron
dc.subject.meshMiddle Aged
dc.subject.meshPhosphopyruvate Hydratase
dc.subject.meshS100 Proteins
dc.subject.meshVimentin
dc.titleChondroid syringoma with hyaline cell change.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital NHS Trust, Manchester, UK.en
dc.identifier.journalHistopathologyen
html.description.abstractFour cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.


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