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    Chondroid syringoma with hyaline cell change.

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    Authors
    Banerjee, Saumitra S
    Harris, Martin
    Eyden, Brian P
    Howell, S
    Wells, S
    Mainwaring, A R
    Affiliation
    Department of Histopathology, Christie Hospital NHS Trust, Manchester, UK.
    Issue Date
    1993-03
    
    Metadata
    Show full item record
    Abstract
    Four cases of chondroid syringoma containing large numbers of hyaline or plasmacytoid cells are described. Three cases occurred in the hand and one in the foot. Hyaline cells are commonly seen in mixed tumours and myoepitheliomas of salivary glands and rarely in chondroid syringomas. The hyaline-cell change in three of the cases initially caused diagnostic difficulties and the possibility of sarcoma was raised in two cases. In addition to the characteristic hyaline cells, the presence of tubulo-glandulo-ductal structures, benign squamous epithelium and myxochondroid stroma aided diagnosis. Immunohistochemically, the hyaline cells exhibited positivity for vimentin, cytokeratin, S-100 protein, carcino-embryonic antigen, focal glial fibrillary acidic protein (3 cases), neuron-specific enolase (3 cases) and focal alpha-smooth muscle actin (2 cases). Occasional cells were Ber EP4 positive (2 cases). In some cells, a striking peripheral ring-like positivity for cytokeratin and S-100 protein was noted. Ultrastructurally, desmosomes, varying numbers of tonofibrils and non-bundling intermediate filaments were seen. Scanty fine filaments with vague focal densities were detected in some cells. Our studies suggest that the hyaline cells represent modified epithelial as well as myoepithelial cells. One of our cases also exhibited collagenous spherulosis.
    Citation
    Chondroid syringoma with hyaline cell change. 1993, 22 (3):235-45 Histopathology
    Journal
    Histopathology
    URI
    http://hdl.handle.net/10541/99793
    DOI
    10.1111/j.1365-2559.1993.tb00113.x
    PubMed ID
    7684353
    Type
    Article
    Language
    en
    ISSN
    0309-0167
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2559.1993.tb00113.x
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