• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Wang, Ji Min
    Kumar, Shant
    Pye, David A
    Van Agthoven, A J
    Krupinski, Jerzy
    Hunter, Robin D
    Affiliation
    Christie Hospital, Manchester, UK.
    Issue Date
    1993-05-28
    
    Metadata
    Show full item record
    Abstract
    A new murine monoclonal antibody (MAb), E-9, has been raised using tissue-cultured human umbilical vein endothelial cells. The antigen recognized by this MAb is a peptide of 170 kDa under non-reducing conditions and 96 kDa under reducing conditions. MAb E-9 showed marked heterogeneity in its distribution in various tissues. The antigen recognized by it was present in vascular endothelial cells of all tumours, foetal organs and in regenerating and inflamed tissues. It stained a few normal tissues. However, with the exception of tonsils, staining tended to be weak and limited to a few blood vessels, as revealed by double staining using pan-endothelial antibody (CD31) and antibody to von Willebrand factor, another marker of vascular endothelium. Surprisingly, blood vessels within the placental villi were completely negative. The function of the antigen recognized by MAb E-9 is not known, but its evaluation and use should increase our understanding of angiogenesis.
    Citation
    A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues. 1993, 54 (3):363-70 Int. J. Cancer
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10541/99786
    DOI
    10.1002/ijc.2910540303
    PubMed ID
    8509210
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.2910540303
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • 4A11, a monoclonal antibody recognizing a novel antigen expressed on aberrant vascular endothelium. Upregulation in an in vivo model of contact dermatitis.
    • Authors: Koch AE, Nickoloff BJ, Holgersson J, Seed B, Haines GK, Burrows JC, Leibovich SJ
    • Issue date: 1994 Feb
    • Lack of specificity of endoglin expression for tumor blood vessels.
    • Authors: Balza E, Castellani P, Zijlstra A, Neri D, Zardi L, Siri A
    • Issue date: 2001 Nov
    • JC70: a new monoclonal antibody that detects vascular endothelium associated antigen on routinely processed tissue sections.
    • Authors: Parums DV, Cordell JL, Micklem K, Heryet AR, Gatter KC, Mason DY
    • Issue date: 1990 Sep
    • Monoclonal antibody-defined human endothelial antigens as vascular markers.
    • Authors: Ruiter DJ, Schlingemann RO, Rietveld FJ, de Waal RM
    • Issue date: 1989 Aug
    • A vascular endothelial cell antigen with restricted distribution in human foetal, adult and malignant tissues.
    • Authors: Cui YC, Tai PC, Gatter KC, Mason DY, Spry CJ
    • Issue date: 1983 May
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.