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    Expression of activated gelatinase in human invasive breast carcinoma.

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    Authors
    Brown, P D
    Bloxidge, R E
    Anderson, Elizabeth
    Howell, Anthony
    Affiliation
    British Bio-technology Ltd, Oxford, UK.
    Issue Date
    1993-03
    
    Metadata
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    Abstract
    The expression of both 92- and 72-kDa gelatinases has been studied in 20 samples of human breast carcinoma by the technique of gelatin zymography. This technique allowed the relative amount of each gelatinase to be determined in small samples of tissue (< 10 mg). More importantly, active and latent forms of the two gelatinases were resolved. Two samples (10-20 mg) were cut from each piece of tumour in order to monitor the variability of gelatinase distribution within that section of tumour. The 72-kDa latent progelatinase was present in 15 of the 20 tumours, with trace amounts in two others. The 62-kDa activated form of this gelatinase was detected in all 15 of the tumours in which the latent form was present. The 92-kDa latent progelatinase was present in 11 of the 20 tumours, with trace amounts in four others. However, the 82-kDa activated form of this gelatinase was only clearly detected in two tumours, although three others showed the presence of trace amounts. The ratio of active to latent forms of the 72-kDa gelatinase ranged from 0.9 to 3.6. There were no marked correlations between gelatinase expression and established staging and prognostic markers. Analysis of three samples of fibroadenoma revealed only very low levels of gelatinase expression. On the basis of these results, activation of the 72-kDa progelatinase appears to be a more common event in invasive breast carcinoma than activation of the 92-kDa progelatinase. However, neither proteinase showed a correlation with metastatic progression, as measured by lymph node involvement.
    Citation
    Expression of activated gelatinase in human invasive breast carcinoma. 1993, 11 (2):183-9 Clin. Exp. Metastasis
    Journal
    Clinical & Experimental Metastasis
    URI
    http://hdl.handle.net/10541/99771
    DOI
    10.1007/BF00114976
    PubMed ID
    8444010
    Type
    Article
    Language
    en
    ISSN
    0262-0898
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00114976
    Scopus Count
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