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dc.contributor.authorEyden, Brian P
dc.contributor.authorChristensen, L
dc.date.accessioned2010-05-24T16:02:33Z
dc.date.available2010-05-24T16:02:33Z
dc.date.issued1993
dc.identifier.citationLeiomyosarcoma versus myofibrosarcoma: observations and terminology., 17 (3-4):231-9 Ultrastruct Patholen
dc.identifier.issn0191-3123
dc.identifier.pmid8266588
dc.identifier.doi10.3109/01913129309027769
dc.identifier.urihttp://hdl.handle.net/10541/99769
dc.description.abstractTwo spindle cell sarcomas, which showed similarities in light microscopic histology and immunostaining and were diagnosed as leiomyosarcomas by these criteria, were compared ultrastructurally to show the value of electron microscopy in subtyping these neoplasms. Both were subcutaneous, case 1 occurring in the nasolabial fold and case 2 in the upper calf. Both consisted of fascicles of spindle cells, and both stained positively for vimentin and alpha-smooth muscle actin; only case 2 stained additionally for desmin. Case 1 showed strong and case 2 weak or negative staining for fibronectin. By electron microscopy, case 1 contained prominent rough endoplasmic reticulum, peripheral fine filaments with focal densities, and fibronexus junctions. By contrast, case 2 was characterized by an external lamina and well-developed bundles of fine filaments with focal densities. Case 2 was considered a typical leiomyosarcoma, and case 1 was interpreted as showing myofibroblastic differentiation. The nomenclature for these myofibroblastic tumors is discussed, and myofibrosarcoma and leiomyosarcoma, myofibroblastic variant are suggested as suitable terms.
dc.language.isoenen
dc.subjectFacial Canceren
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshFacial Neoplasms
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry
dc.subject.meshLeg
dc.subject.meshLeiomyosarcoma
dc.subject.meshMicroscopy, Electron
dc.subject.meshMyosarcoma
dc.subject.meshPhenotype
dc.subject.meshTerminology as Topic
dc.titleLeiomyosarcoma versus myofibrosarcoma: observations and terminology.en
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Christie Hospital National Health Service Trust, Manchester, United Kingdom.en
dc.identifier.journalUltrastructural Pathologyen
html.description.abstractTwo spindle cell sarcomas, which showed similarities in light microscopic histology and immunostaining and were diagnosed as leiomyosarcomas by these criteria, were compared ultrastructurally to show the value of electron microscopy in subtyping these neoplasms. Both were subcutaneous, case 1 occurring in the nasolabial fold and case 2 in the upper calf. Both consisted of fascicles of spindle cells, and both stained positively for vimentin and alpha-smooth muscle actin; only case 2 stained additionally for desmin. Case 1 showed strong and case 2 weak or negative staining for fibronectin. By electron microscopy, case 1 contained prominent rough endoplasmic reticulum, peripheral fine filaments with focal densities, and fibronexus junctions. By contrast, case 2 was characterized by an external lamina and well-developed bundles of fine filaments with focal densities. Case 2 was considered a typical leiomyosarcoma, and case 1 was interpreted as showing myofibroblastic differentiation. The nomenclature for these myofibroblastic tumors is discussed, and myofibrosarcoma and leiomyosarcoma, myofibroblastic variant are suggested as suitable terms.


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