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    Inverse relationship between hyaluronan and collagens in development and angiogenesis.

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    Authors
    Rooney, P
    Kumar, Shant
    Affiliation
    Department of Pathological Sciences, University of Manchester, UK.
    Issue Date
    1993-08
    
    Metadata
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    Abstract
    The extracellular matrix plays a vital role in regulating normal tissue development and function--largely via the specific arrangement of macromolecules such as collagens, proteoglycans, glycosaminoglycans and glycoproteins. Previous reports have concentrated on associations between combinations of collagens/proteoglycans, collagens/glycoproteins and proteoglycans/glycosaminoglycans whilst little information is available on associations between collagens and free glycosaminoglycans. In this review, we discuss possible associations between collagens and the glycosaminoglycan hyaluronan; macromolecules which are known to exhibit changes in amount and composition during development and under pathological conditions. We demonstrate two types of collagen/hyaluronan association in vivo: the first, during the formation of extracellular matrix structures where neither collagens nor hyaluronan are degraded, resulting in the regulation of collagen fibrillogenesis, and the second, involving an inverse correlation between collagen synthesis and hyaluronan degradation and vice versa. We suggest that associations between collagens and hyaluronan play an important role in the initiation and maintenance of angiogenesis and put forward a model of cartilage vascularisation which relies on these associations.
    Citation
    Inverse relationship between hyaluronan and collagens in development and angiogenesis. 1993, 54 (1):1-9 Differentiation
    Journal
    Differentiation
    URI
    http://hdl.handle.net/10541/99767
    DOI
    10.1111/j.1432-0436.1993.tb00653.x
    PubMed ID
    7691668
    Type
    Article
    Language
    en
    ISSN
    0301-4681
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1432-0436.1993.tb00653.x
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