Inverse relationship between hyaluronan and collagens in development and angiogenesis.
Affiliation
Department of Pathological Sciences, University of Manchester, UK.Issue Date
1993-08
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The extracellular matrix plays a vital role in regulating normal tissue development and function--largely via the specific arrangement of macromolecules such as collagens, proteoglycans, glycosaminoglycans and glycoproteins. Previous reports have concentrated on associations between combinations of collagens/proteoglycans, collagens/glycoproteins and proteoglycans/glycosaminoglycans whilst little information is available on associations between collagens and free glycosaminoglycans. In this review, we discuss possible associations between collagens and the glycosaminoglycan hyaluronan; macromolecules which are known to exhibit changes in amount and composition during development and under pathological conditions. We demonstrate two types of collagen/hyaluronan association in vivo: the first, during the formation of extracellular matrix structures where neither collagens nor hyaluronan are degraded, resulting in the regulation of collagen fibrillogenesis, and the second, involving an inverse correlation between collagen synthesis and hyaluronan degradation and vice versa. We suggest that associations between collagens and hyaluronan play an important role in the initiation and maintenance of angiogenesis and put forward a model of cartilage vascularisation which relies on these associations.Citation
Inverse relationship between hyaluronan and collagens in development and angiogenesis. 1993, 54 (1):1-9 DifferentiationJournal
DifferentiationDOI
10.1111/j.1432-0436.1993.tb00653.xPubMed ID
7691668Type
ArticleLanguage
enISSN
0301-4681ae974a485f413a2113503eed53cd6c53
10.1111/j.1432-0436.1993.tb00653.x
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