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    Biology of blood progenitor cells used in transplantation.

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    Authors
    Pettengell, Ruth
    Testa, Nydia G
    Affiliation
    CRC Department of Medical Oncology, Christie Hospital, Manchester, UK.
    Issue Date
    1995-01
    
    Metadata
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    Abstract
    Blood progenitor cells (BPC) are increasingly used in a variety of clinical settings. These include autologous and allogeneic transplantation after myeloablative therapy, and gene therapy. The optimal blood products for each of these applications have not been defined. The use of different cytotoxic drugs and cytokines, alone and in combination, results in the mobilisation of different total numbers and relative proportions of primitive and committed BPC. Some cytotoxics and cytokines not only are poor at mobilising BPC, but also are myelotoxic. Here we review the biology of BPC mobilisation and its implications for their clinical use.
    Citation
    Biology of blood progenitor cells used in transplantation. 1995, 61 (1):1-15 Int. J. Hematol.
    Journal
    International Journal of Hematology
    URI
    http://hdl.handle.net/10541/99444
    PubMed ID
    7718764
    Type
    Article
    Language
    en
    ISSN
    0925-5710
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

    entitlement

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