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    Alternate splicing produces a novel cyclin D1 transcript.

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    Authors
    Betticher, Daniel C
    Thatcher, Nick
    Altermatt, H J
    Hoban, P
    Ryder, W David J
    Heighway, Jim
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
    Issue Date
    1995-09-07
    
    Metadata
    Show full item record
    Abstract
    Using Northern blotting and PCR analysis of cDNA derived from a range of cell lines and tissues, alternate splicing of the cyclin D1 gene (CCND1) mRNA has been demonstrated. The variant transcript shows no splicing at the downstream exon 4 boundary, encoding a protein with an altered carboxy-terminal domain. Investigation of mRNA extracted from mononuclear cells, lung tumour and normal tissue suggests that both transcripts are invariably expressed. However, splicing to produce the two forms of mRNA is modulated, in the heterozygote, by a frequent A/G polymorphism located within the splice donor region of exon 4. Preliminary analysis of patients with resectable non-small cell lung cancer suggests that genotype is associated with shortened event free survival and greater risk of local relapse.
    Citation
    Alternate splicing produces a novel cyclin D1 transcript. 1995, 11 (5):1005-11 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/99426
    PubMed ID
    7675441
    Type
    Article
    Language
    en
    ISSN
    0950-9232
    Collections
    All Christie Publications
    All Paterson Institute for Cancer Research

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