Volunteers or victims: patients' views of randomised cancer clinical trials.
Steward, William P
AffiliationDepartment of Medical Oncology, St Bartholomew's Hospital, West Smithfield, London, UK.
MetadataShow full item record
AbstractRandomised clinical trials are essential for the objective evaluation of different treatment strategies in cancer. However, in the field of oncology, very few of the eligible patients are entered into trials, and most treatments have only been tested on a small percentage of patients. For doctors, a major deterrent to participating in trials is the lack of resources--particularly time, but often also the local facilities. This report suggests that patients themselves are willing to take part in clinical research, and are attracted by being treated by a doctor with a specialist interest in the disease and encouraged by the possibility that their progress will be monitored closely. With the recent NHS changes, it is timely for the Department of Health and other national health departments to consider carefully what can be done to ensure that no new treatments are adopted without effective evaluation. This will require departments of health to identify and implement ways to facilitate accrual of appropriate numbers of patients onto research protocols (whether non-randomised phase I or phase II studies or large, multicentre phase III trials) over short time periods.
CitationVolunteers or victims: patients' views of randomised cancer clinical trials. 1995, 71 (6):1270-4 Br. J. Cancer
JournalBritish Journal of Cancer
- [An index of understanding randomised clinical trials in oncology].
- Authors: Leroy T, Christophe V, Penel N, Antoine P, Vanlemmens L, Reich M, Clisant S
- Issue date: 2009 Jun
- Results of an intervention study to improve communication about randomised clinical trials of cancer therapy.
- Authors: Fleissig A, Jenkins V, Fallowfield L
- Issue date: 2001 Feb
- Lay public's understanding of equipoise and randomisation in randomised controlled trials.
- Authors: Robinson EJ, Kerr CE, Stevens AJ, Lilford RJ, Braunholtz DA, Edwards SJ, Beck SR, Rowley MG
- Issue date: 2005 Mar
- Locally advanced non-small cell lung cancer: do we know the questions? A survey of randomized trials from 1966-1993.
- Authors: Brundage MD, Mackillop WJ
- Issue date: 1996 Feb
- Improving accrual of older persons to cancer treatment trials: a randomized trial comparing an educational intervention with standard information: CALGB 360001.
- Authors: Kimmick GG, Peterson BL, Kornblith AB, Mandelblatt J, Johnson JL, Wheeler J, Heinze R, Cohen HJ, Muss HB
- Issue date: 2005 Apr 1