• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Howell, Anthony
    DeFriend, D
    Robertson, J
    Blamey, R
    Walton, P
    Affiliation
    CRC Department of Medical Oncology, University of Manchester, Christie Hospital, UK.
    Issue Date
    1995-01-07
    
    Metadata
    Show full item record
    Abstract
    We treated 19 patients with advanced breast cancer resistant to tamoxifen with a new specific antioestrogen (ICI 182780) which, in animal studies, has no agonist activity. 13 (69%) patients responded (7 had partial responses and 6 showed no change) to monthly intramuscular injections of ICI 182780 after progression on tamoxifen, for a median duration of 18 months with minimum side effects. Preliminary evidence suggests that the agent is without effects on the liver or the hypothalamic-pituitary axis. ICI 182780 appears to be a promising new agent for treatment of advanced and early breast cancer.
    Citation
    Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer. 1995, 345 (8941):29-30 Lancet
    Journal
    Lancet
    URI
    http://hdl.handle.net/10541/99252
    DOI
    10.1016/S0140-6736(95)91156-1
    PubMed ID
    7799704
    Type
    Article
    Language
    en
    ISSN
    0140-6736
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(95)91156-1
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer.
    • Authors: Howell A, Robertson J
    • Issue date: 1995 Apr 15
    • ICI 182,780 (Fulvestrant)--the first oestrogen receptor down-regulator--current clinical data.
    • Authors: Robertson JF
    • Issue date: 2001 Nov
    • Effects of 4-hydroxytamoxifen and a novel pure antioestrogen (ICI 182780) on the clonogenic growth of human breast cancer cells in vitro.
    • Authors: DeFriend DJ, Anderson E, Bell J, Wilks DP, West CM, Mansel RE, Howell A
    • Issue date: 1994 Aug
    • Response to specific anti-oestrogen (ICI182780) in tamoxifen-resistant breast cancer.
    • Authors: Dowsett M, Johnston SR, Iveson TJ, Smith IE
    • Issue date: 1995 Feb 25
    • Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer.
    • Authors: Howell A, DeFriend DJ, Robertson JF, Blamey RW, Anderson L, Anderson E, Sutcliffe FA, Walton P
    • Issue date: 1996 Jul
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.