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dc.contributor.authorTaylor, G M
dc.contributor.authorRobinson, M D
dc.contributor.authorBinchy, A
dc.contributor.authorBirch, Jillian M
dc.contributor.authorStevens, R F
dc.contributor.authorJones, P M
dc.contributor.authorCarr, T
dc.contributor.authorDearden, S
dc.contributor.authorGokhale, D A
dc.date.accessioned2010-05-19T11:10:39Z
dc.date.available2010-05-19T11:10:39Z
dc.date.issued1995-03
dc.identifier.citationPreliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology. 1995, 9 (3):440-3 Leukemiaen
dc.identifier.issn0887-6924
dc.identifier.pmid7885043
dc.identifier.urihttp://hdl.handle.net/10541/99249
dc.description.abstractIt has been suggested that childhood leukaemia may be the abnormal outcome of a common infection. Rare events caused by common environmental events such as infections are likely to be influenced by host genetic susceptibility. We have therefore investigated whether immunogenetic susceptibility contributes to the risk of childhood common ALL (c-ALL). In this preliminary study, we report that children with c-ALL (n = 63) carry the HLA-DPB1 locus allele *0201 twice and nearly three times more frequently than adult (n = 92; relative risk (RR) = 2.9, P < 0.05) or infant controls (n = 82; RR = 2.1). Moreover, children with c-ALL are 3-4 times more likely than controls to be heterozygous for DPB1*0201/*0301, /*0401 and /*0402 (RRadult controls = 3.9; RRinfant controls = 2.8). These results suggest that HLA-DPB1*0201 either alone or with other DPB1 alleles contributes to the risk of childhood c-ALL, possibly by increasing susceptibility to an infectious agent.
dc.language.isoenen
dc.subjectPrecursor B-Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent
dc.subject.meshAlleles
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshDisease Susceptibility
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenotype
dc.subject.meshHLA-DP Antigens
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshInfection
dc.subject.meshMale
dc.subject.meshPolymerase Chain Reaction
dc.subject.meshPrecursor B-Cell Lymphoblastic Leukemia-Lymphoma
dc.titlePreliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.en
dc.typeArticleen
dc.contributor.departmentImmunogenetics Laboratory, St Mary's Hospital, Manchester, UK.en
dc.identifier.journalLeukemiaen
html.description.abstractIt has been suggested that childhood leukaemia may be the abnormal outcome of a common infection. Rare events caused by common environmental events such as infections are likely to be influenced by host genetic susceptibility. We have therefore investigated whether immunogenetic susceptibility contributes to the risk of childhood common ALL (c-ALL). In this preliminary study, we report that children with c-ALL (n = 63) carry the HLA-DPB1 locus allele *0201 twice and nearly three times more frequently than adult (n = 92; relative risk (RR) = 2.9, P < 0.05) or infant controls (n = 82; RR = 2.1). Moreover, children with c-ALL are 3-4 times more likely than controls to be heterozygous for DPB1*0201/*0301, /*0401 and /*0402 (RRadult controls = 3.9; RRinfant controls = 2.8). These results suggest that HLA-DPB1*0201 either alone or with other DPB1 alleles contributes to the risk of childhood c-ALL, possibly by increasing susceptibility to an infectious agent.


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