Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology.
Authors
Taylor, G MRobinson, M D
Binchy, A
Birch, Jillian M
Stevens, R F
Jones, P M
Carr, T
Dearden, S
Gokhale, D A
Affiliation
Immunogenetics Laboratory, St Mary's Hospital, Manchester, UK.Issue Date
1995-03
Metadata
Show full item recordAbstract
It has been suggested that childhood leukaemia may be the abnormal outcome of a common infection. Rare events caused by common environmental events such as infections are likely to be influenced by host genetic susceptibility. We have therefore investigated whether immunogenetic susceptibility contributes to the risk of childhood common ALL (c-ALL). In this preliminary study, we report that children with c-ALL (n = 63) carry the HLA-DPB1 locus allele *0201 twice and nearly three times more frequently than adult (n = 92; relative risk (RR) = 2.9, P < 0.05) or infant controls (n = 82; RR = 2.1). Moreover, children with c-ALL are 3-4 times more likely than controls to be heterozygous for DPB1*0201/*0301, /*0401 and /*0402 (RRadult controls = 3.9; RRinfant controls = 2.8). These results suggest that HLA-DPB1*0201 either alone or with other DPB1 alleles contributes to the risk of childhood c-ALL, possibly by increasing susceptibility to an infectious agent.Citation
Preliminary evidence of an association between HLA-DPB1*0201 and childhood common acute lymphoblastic leukaemia supports an infectious aetiology. 1995, 9 (3):440-3 LeukemiaJournal
LeukemiaPubMed ID
7885043Type
ArticleLanguage
enISSN
0887-6924Collections
Related articles
- Strong association of the HLA-DP6 supertype with childhood leukaemia is due to a single allele, DPB1*0601.
- Authors: Taylor GM, Hussain A, Verhage V, Thompson PD, Fergusson WD, Watkins G, Lightfoot T, Harrison CJ, Birch JM, UKCCS Investigators.
- Issue date: 2009 May
- HLA-DPB1 supertype-associated protection from childhood leukaemia: relationship to leukaemia karyotype and implications for prevention.
- Authors: Taylor M, Harrison C, Eden T, Birch J, Greaves M, Lightfoot T, Hussain A, UKCCS Investigators.
- Issue date: 2008 Jan
- HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy.
- Authors: Chinoy H, Payne D, Poulton KV, Fertig N, Betteridge Z, Gunawardena H, Davidson JE, Oddis CV, McHugh NJ, Wedderburn LR, Ollier WE, Cooper RG, UK Adult Onset Myositis Immunogenetic Collaboration & UK Juvenile Dermatomyositis Research Group.
- Issue date: 2009 Oct
- HLA-DQB1 and -DPB1 allele profile in HIV infected patients with and without pulmonary tuberculosis of south India.
- Authors: Selvaraj P, Raghavan S, Swaminathan S, Alagarasu K, Narendran G, Narayanan PR
- Issue date: 2008 Sep
- Association of HLA class II DRB1, DPA1 and DPB1 polymorphism with genetic susceptibility to idiopathic dilated cardiomyopathy in Chinese Han nationality.
- Authors: Liu W, Li WM, Yang SS, Gao C, Li SJ, Li Y, Kong YH, Gan RT
- Issue date: 2006 Sep