Tropisetron alone or in combination with dexamethasone for the prevention and treatment of emesis induced by non-cisplatin chemotherapy: a randomized trial.
Trask, C W
De Bruijn, K M
AffiliationVelindre Hospital, Whitchurch, Cardiff, UK.
MetadataShow full item record
AbstractThis study compared the efficacy and tolerability of tropisetron (Navoban, Novaban) alone or in combination with dexamethasone for the treatment of emesis induced by moderately emetogenic non-cisplatin chemotherapy. In total, 126 patients with cancer, who had never received chemotherapy and who required at least two courses of moderately emetogenic non-cisplatin chemotherapy each lasting for a minimum of 5 days, were recruited into the study. Patients were randomized to receive tropisetron, 5 mg o.d., plus either dexamethasone, 12 mg i.v. on day 1 followed by 4 mg orally b.i.d. on days 2-5, or placebo. Greater control of acute and delayed vomiting and nausea was achieved in patients given the tropisetron-dexamethasone combination than in those who received the tropisetron-placebo treatment. The majority of adverse events were mild and could be attributed to the chemotherapeutic regimen used or to the underlying disease. Patients and investigators both rated tropisetron alone or in combination with dexamethasone as a highly effective and well-tolerated antiemetic treatment. The results of this study show that tropisetron, 5 mg o.d., is an effective, well-tolerated and simple to use antiemetic treatment for patients receiving moderately emetogenic non-cisplatin chemotherapy. The addition of dexamethasone increases the efficacy of tropisetron without significantly decreasing its tolerability.
CitationTropisetron alone or in combination with dexamethasone for the prevention and treatment of emesis induced by non-cisplatin chemotherapy: a randomized trial. 1995, 6 (4):514-21 Anticancer Drugs
- Tropisetron (Navoban) alone and in combination with dexamethasone in the prevention of chemotherapy-induced emesis: the Nordic experience.
- Authors: Sorbe BG
- Issue date: 1994 Oct
- Prevention of chemotherapy-induced nausea and vomiting by tropisetron (Navoban) alone or in combination with other antiemetic agents.
- Authors: Bruntsch U, Drechsler S, Eggert J, Gosse H, Ukena D, Imhoff W, Faerber L
- Issue date: 1994 Oct
- An open multicentre study of tropisetron for cisplatin-induced nausea and vomiting.
- Authors: Olver IN, Craft PS, Clingan PR, Kearsley JH, Planner RS, van Hazel GA, Bell DR, Adena MR, Hall BE, Pearson LL
- Issue date: 1996 Mar 18
- Study of efficacy and tolerability of tropisetron in the prevention of cisplatin induced nausea and vomiting.
- Authors: Chiersilpa A, Ngow J
- Issue date: 1999 Sep
- A study evaluating the efficacy and tolerability of tropisetron in combination with dexamethasone in the prevention of delayed platinum-induced nausea and emesis.
- Authors: Sorbe BG, Berglind AM, Andersson H, Boman K, Högberg T, Hallgren M, Schmidt M
- Issue date: 1998 Sep 1