AffiliationCRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester.
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AbstractThe overall median survival of patients with systemic metastasis from melanoma is about 6 months. Survival is dependent on the sites of first metastasis, the resectability of the metastases, and the number of metastases. Patients with non-visceral metastases at first relapse i.e. in skin, subcutaneous tissues, distant lymph nodes, and lung, have a better survival rate than patients with visceral (liver, bone, brain) metastases. Treatment of patients with systemic melanoma should include careful evaluation for the potential role of surgery, radiotherapy, and systemic therapy. The main use of chemotherapy in metastatic melanoma patients remains palliative. The chapter reviews the chemotherapeutic options available for the treatment of malignant melanoma including recent published works on new agents, multi-agent therapy, high dose chemotherapy with autologous bone marrow rescue, adjuvant chemotherapy and regional perfusion chemotherapy.
CitationMelanoma: chemotherapy. 1995, 51 (3):609-30 Br. Med. Bull.
JournalBritish Medical Bulletin
- Impact of regional chemotherapy for melanoma metastases.
- Authors: Voigt H
- Issue date: 1988 May-Jun
- Curative and palliative aspects of regional chemotherapy in combination with surgery.
- Authors: Müller H, Hilger R
- Issue date: 2003 Jan
- Randomized trial of high-dose chemotherapy with autologous bone marrow support as adjuvant therapy for high-risk, multi-node-positive malignant melanoma.
- Authors: Meisenberg BR, Ross M, Vredenburgh JJ, Jones R, Shpall EJ, Seigler HF, Coniglio DM, Wu K, Peters WP
- Issue date: 1993 Jul 7
- Evidence-based and interdisciplinary consensus-based German guidelines: systemic medical treatment of melanoma in the adjuvant and palliative setting.
- Authors: Garbe C, Hauschild A, Volkenandt M, Schadendorf D, Stolz W, Reinhold U, Kortmann RD, Kettelhack C, Frerich B, Keilholz U, Dummer R, Sebastian G, Tilgen W, Schuler G, Mackensen A, Kaufmann R
- Issue date: 2008 Apr
- Surgical issues in the management of melanoma.
- Authors: Fraker DL
- Issue date: 1997 Mar