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dc.contributor.authorNew, N E
dc.contributor.authorBishop, P W
dc.contributor.authorStewart, M
dc.contributor.authorBanerjee, Saumitra S
dc.contributor.authorHarris, Martin
dc.date.accessioned2010-05-18T12:05:49Z
dc.date.available2010-05-18T12:05:49Z
dc.date.issued1995-01
dc.identifier.citationInflammatory pseudotumour of lymph nodes. 1995, 48 (1):37-40 J. Clin. Pathol.en
dc.identifier.issn0021-9746
dc.identifier.pmid7706516
dc.identifier.doi10.1136/jcp.48.1.37
dc.identifier.urihttp://hdl.handle.net/10541/99091
dc.description.abstractAIM: To describe the clinical, histological and immunohistochemical features in four cases of an uncommon benign lymph node lesion which may mimic a neoplastic process. METHODS: Four cases of inflammatory pseudotumour of lymph nodes were studied using conventional staining (haematoxylin and eosin, PAS, Gordon and Sweets reticulin stain, and the Ziehl-Neelsen stain) and with immunohistochemical techniques using a variety of antibodies (CD3, L26, CD15, CD21, CD30, KP1, MAC 387, vimentin, alpha SMA, HHF-35, D33, CD34, and S100). RESULTS: The lesion comprises a proliferation of spindle cells expanding the connective tissue framework of lymph nodes and is associated with a plasma cell and small lymphocyte infiltrate. There are variable numbers of macrophages, neutrophils and eosinophils, and varying degrees of fibrosis. Vascular changes are common but vary in degree and type. CONCLUSIONS: Inflammatory pseudotumour of lymph nodes is an uncommon benign reaction pattern which may be misdiagnosed as a neoplastic or even a malignant process. Increased awareness of its histological features should help prevent such misdiagnoses.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshDiagnosis, Differential
dc.subject.meshFemale
dc.subject.meshGranuloma, Plasma Cell
dc.subject.meshHumans
dc.subject.meshImmune Sera
dc.subject.meshLymphatic Diseases
dc.subject.meshLymphocytes
dc.subject.meshLymphoma
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPlasma Cells
dc.subject.meshRetrospective Studies
dc.titleInflammatory pseudotumour of lymph nodes.en
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, Christie Hospital NHS Trust, Withington, Manchester.en
dc.identifier.journalJournal of Clinical Pathologyen
refterms.dateFOA2020-04-21T10:58:19Z
html.description.abstractAIM: To describe the clinical, histological and immunohistochemical features in four cases of an uncommon benign lymph node lesion which may mimic a neoplastic process. METHODS: Four cases of inflammatory pseudotumour of lymph nodes were studied using conventional staining (haematoxylin and eosin, PAS, Gordon and Sweets reticulin stain, and the Ziehl-Neelsen stain) and with immunohistochemical techniques using a variety of antibodies (CD3, L26, CD15, CD21, CD30, KP1, MAC 387, vimentin, alpha SMA, HHF-35, D33, CD34, and S100). RESULTS: The lesion comprises a proliferation of spindle cells expanding the connective tissue framework of lymph nodes and is associated with a plasma cell and small lymphocyte infiltrate. There are variable numbers of macrophages, neutrophils and eosinophils, and varying degrees of fibrosis. Vascular changes are common but vary in degree and type. CONCLUSIONS: Inflammatory pseudotumour of lymph nodes is an uncommon benign reaction pattern which may be misdiagnosed as a neoplastic or even a malignant process. Increased awareness of its histological features should help prevent such misdiagnoses.


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