Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency.
Affiliation
Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK.Issue Date
1995-06
Metadata
Show full item recordAbstract
OBJECTIVE: Previous studies of the effect of GH replacement on bone mass in adults with GH deficiency have produced conflicting results. We have studied the effect of 6 and 12 months of GH replacement on bone mass in adults with adult onset GH deficiency. DESIGN: Double blind placebo controlled study of GH replacement (0.125 IU/kg/week for the first month and 0.25 IU/kg/week thereafter) for 6 months and an open study for a further 6 or 12 months. PATIENTS: Twenty-two adults (10 men, 12 women), aged 41.5 +/- 2.1 years (mean +/- SE, range 23.6-59.5), with adult onset GH deficiency. MEASUREMENTS: Single-energy quantitative computed tomography was used to measure vertebral trabecular bone mineral density (BMD), single-photon absorptiometry (SPA) was used to measure forearm cortical and integral bone mineral content and BMD and dual-energy X-ray absorptiometry (DXA) was used to measure lumbar spine, femoral neck, trochanteric and Ward's triangle integral BMD. RESULTS: After 6 months of GH replacement (n = 21) there was a significant decrease in forearm cortical BMD (SPA: median change -0.009 g/cm2, P = 0.01), forearm integral BMD (SPA: median change -0.016 g/cm2, P = 0.03), lumbar spine BMD (DXA: median change -0.22 g/cm2; P = 0.003) and femoral neck BMD (DXA: median change -0.029 g/cm2, P = 0.006). After 12 months of GH replacement (n = 13) there was a significant decrease in lumbar spine BMD (DXA: median change -0.035 g/cm2, P = 0.002) from baseline. There was no significant increase in bone mass at any site after 6 or 12 months of GH replacement. Change in bone mass was not influenced by sex of the patient or by presence or absence of additional pituitary hormone deficiencies. CONCLUSION: The response of bone mass to 6 and 12 months of GH replacement in adults with adult onset GH deficiency is disappointing. Longer-term studies are required to determine whether prolonged GH replacement has a beneficial effect on bone mass.Citation
Effect of growth hormone replacement on bone mass in adults with adult onset growth hormone deficiency. 1995, 42 (6):627-33 Clin. EndocrinolJournal
Clinical EndocrinologyDOI
10.1111/j.1365-2265.1995.tb02690.xPubMed ID
7634504Type
ArticleLanguage
enISSN
0300-0664ae974a485f413a2113503eed53cd6c53
10.1111/j.1365-2265.1995.tb02690.x
Scopus Count
Collections
Related articles
- Long-term change in the bone mineral density of adults with adult onset growth hormone (GH) deficiency in response to short or long-term GH replacement therapy.
- Authors: Rahim A, Holmes SJ, Adams JE, Shalet SM
- Issue date: 1998 Apr
- Effects of growth hormone (GH) replacement on bone metabolism and mineral density in adult onset of GH deficiency: results of a double-blind placebo-controlled study with open follow-up.
- Authors: Finkenstedt G, Gasser RW, Höfle G, Watfah C, Fridrich L
- Issue date: 1997 Mar
- Reduced bone mineral density in patients with adult onset growth hormone deficiency.
- Authors: Holmes SJ, Economou G, Whitehouse RW, Adams JE, Shalet SM
- Issue date: 1994 Mar
- Further increase in forearm cortical bone mineral content after discontinuation of growth hormone replacement.
- Authors: Holmes SJ, Whitehouse RW, Economou G, O'Halloran DJ, Adams JE, Shalet SM
- Issue date: 1995 Jan
- The influence of gender on the short and long-term effects of growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults: a 5-year study.
- Authors: Drake WM, Rodríguez-Arnao J, Weaver JU, James IT, Coyte D, Spector TD, Besser GM, Monson JP
- Issue date: 2001 Apr