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dc.contributor.authorChadderton, R D
dc.contributor.authorWest, C G
dc.contributor.authorSchuller, S
dc.contributor.authorQuirke, D C
dc.contributor.authorGattamaneni, Rao
dc.contributor.authorTaylor, R
dc.date.accessioned2010-05-10T16:14:50Z
dc.date.available2010-05-10T16:14:50Z
dc.date.issued1995-08
dc.identifier.citationRadiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae. 1995, 11 (8):443-8 Childs Nerv Systen
dc.identifier.issn0256-7040
dc.identifier.pmid7585679
dc.identifier.doi10.1007/BF00334961
dc.identifier.urihttp://hdl.handle.net/10541/98384
dc.description.abstractThe purpose of the present study was to define the late effects, both physical and psychological, of treating low-grade astrocytomas with radiotherapy. Fifty patients, half of whom received radiotherapy, underwent an assessment of neurological and neuropsychological function. There was no difference in neurological function between the two groups. The radiotherapy recipients, including those with cerebellar tumours, performed significantly worse on measures of intelligence and information processing. In addition, there was a greater incidence of special education needs in the irradiated group. We conclude that children with low-grade astrocytomas who receive radiotherapy have no greater neurological deficit but that the use of radiotherapy carries a penalty in terms of long-term cognitive function and confirmed the findings of many previous reports that supratentorial irradiation is detrimental. More surprisingly, it has been demonstrated that local field irradiation to the posterior fossa can also produce significant cognitive impairment.
dc.language.isoenen
dc.subjectBrain Canceren
dc.subject.meshAdolescent
dc.subject.meshAstrocytoma
dc.subject.meshBrain
dc.subject.meshBrain Neoplasms
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCognition Disorders
dc.subject.meshCombined Modality Therapy
dc.subject.meshCranial Irradiation
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshIntelligence
dc.subject.meshMale
dc.subject.meshMental Recall
dc.subject.meshNeurologic Examination
dc.subject.meshNeuropsychological Tests
dc.subject.meshRadiation Injuries
dc.subject.meshRadiotherapy, Adjuvant
dc.subject.meshReading
dc.titleRadiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae.en
dc.typeArticleen
dc.contributor.departmentDepartment of Neurological Surgery, Royal Manchester Children's Hospital, UK.en
dc.identifier.journalChild's Nervous Systemen
html.description.abstractThe purpose of the present study was to define the late effects, both physical and psychological, of treating low-grade astrocytomas with radiotherapy. Fifty patients, half of whom received radiotherapy, underwent an assessment of neurological and neuropsychological function. There was no difference in neurological function between the two groups. The radiotherapy recipients, including those with cerebellar tumours, performed significantly worse on measures of intelligence and information processing. In addition, there was a greater incidence of special education needs in the irradiated group. We conclude that children with low-grade astrocytomas who receive radiotherapy have no greater neurological deficit but that the use of radiotherapy carries a penalty in terms of long-term cognitive function and confirmed the findings of many previous reports that supratentorial irradiation is detrimental. More surprisingly, it has been demonstrated that local field irradiation to the posterior fossa can also produce significant cognitive impairment.


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