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    Radiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae.

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    Authors
    Chadderton, R D
    West, C G
    Schuller, S
    Quirke, D C
    Gattamaneni, Rao
    Taylor, R
    Affiliation
    Department of Neurological Surgery, Royal Manchester Children's Hospital, UK.
    Issue Date
    1995-08
    
    Metadata
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    Abstract
    The purpose of the present study was to define the late effects, both physical and psychological, of treating low-grade astrocytomas with radiotherapy. Fifty patients, half of whom received radiotherapy, underwent an assessment of neurological and neuropsychological function. There was no difference in neurological function between the two groups. The radiotherapy recipients, including those with cerebellar tumours, performed significantly worse on measures of intelligence and information processing. In addition, there was a greater incidence of special education needs in the irradiated group. We conclude that children with low-grade astrocytomas who receive radiotherapy have no greater neurological deficit but that the use of radiotherapy carries a penalty in terms of long-term cognitive function and confirmed the findings of many previous reports that supratentorial irradiation is detrimental. More surprisingly, it has been demonstrated that local field irradiation to the posterior fossa can also produce significant cognitive impairment.
    Citation
    Radiotherapy in the treatment of low-grade astrocytomas. II. The physical and cognitive sequelae. 1995, 11 (8):443-8 Childs Nerv Syst
    Journal
    Child's Nervous System
    URI
    http://hdl.handle.net/10541/98384
    DOI
    10.1007/BF00334961
    PubMed ID
    7585679
    Type
    Article
    Language
    en
    ISSN
    0256-7040
    ae974a485f413a2113503eed53cd6c53
    10.1007/BF00334961
    Scopus Count
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    All Christie Publications

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