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dc.contributor.authorDidi, Mohammeden
dc.contributor.authorDidcock, Een
dc.contributor.authorDavies, H Aen
dc.contributor.authorOgilvy-Stuart, Amanda Len
dc.contributor.authorWales, J Ken
dc.contributor.authorShalet, Stephen Men
dc.date.accessioned2010-05-06T16:22:23Z
dc.date.available2010-05-06T16:22:23Z
dc.date.issued1995-07
dc.identifier.citationHigh incidence of obesity in young adults after treatment of acute lymphoblastic leukemia in childhood. 1995, 127 (1):63-7 J. Pediatr.en
dc.identifier.issn0022-3476
dc.identifier.pmid7608813
dc.identifier.doi10.1016/S0022-3476(95)70258-X
dc.identifier.urihttp://hdl.handle.net/10541/98098
dc.description.abstractTo determine whether obesity complicated the treatment of childhood acute lymphoblastic leukemia, we studied the body mass index (BMI) of 63 female when and 51 male patients from the time of diagnosis of acute lymphoblastic leukemia to the time when final height was attained. The BMI z score was calculated for each patient at diagnosis, at end of treatment, and at attainment of final height. Obesity at attainment of final height was defined as a BMI greater than the 85th percentile of the normal reference population. At final height 23 of 51 male (45%) and 30 of 63 female patients (47%) were obese. Girls became obese between diagnosis and the end of chemotherapy (p = 0.02), after which they had no further increase, indicating that chemotherapy may have played a role in their obesity. Boys had a progressive and gradual increase in BMI z score through to attainment of final height. Obesity did not appear to be associated with growth hormone insufficiency, disproportionate growth, or abnormal timing of puberty. We conclude that approximately half the survivors of leukemia in childhood become obese young adults. Many of those treated with the more recent regimens studied are still only in their mid or preteen years and should be advised regarding a more active lifestyle and a healthy diet in an attempt to reduce the incidence of obesity.
dc.language.isoenen
dc.subjectPrecursor Cell Lymphoblastic Leukaemia-Lymphomaen
dc.subject.meshAdolescent
dc.subject.meshBody Height
dc.subject.meshBody Mass Index
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshGreat Britain
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshMale
dc.subject.meshObesity
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma
dc.titleHigh incidence of obesity in young adults after treatment of acute lymphoblastic leukemia in childhood.en
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Christie Hospital, NHS Trust, Manchester, United Kingdom.en
dc.identifier.journalThe Journal of Pediatricsen
html.description.abstractTo determine whether obesity complicated the treatment of childhood acute lymphoblastic leukemia, we studied the body mass index (BMI) of 63 female when and 51 male patients from the time of diagnosis of acute lymphoblastic leukemia to the time when final height was attained. The BMI z score was calculated for each patient at diagnosis, at end of treatment, and at attainment of final height. Obesity at attainment of final height was defined as a BMI greater than the 85th percentile of the normal reference population. At final height 23 of 51 male (45%) and 30 of 63 female patients (47%) were obese. Girls became obese between diagnosis and the end of chemotherapy (p = 0.02), after which they had no further increase, indicating that chemotherapy may have played a role in their obesity. Boys had a progressive and gradual increase in BMI z score through to attainment of final height. Obesity did not appear to be associated with growth hormone insufficiency, disproportionate growth, or abnormal timing of puberty. We conclude that approximately half the survivors of leukemia in childhood become obese young adults. Many of those treated with the more recent regimens studied are still only in their mid or preteen years and should be advised regarding a more active lifestyle and a healthy diet in an attempt to reduce the incidence of obesity.


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