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    High incidence of obesity in young adults after treatment of acute lymphoblastic leukemia in childhood.

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    Authors
    Didi, Mohammed
    Didcock, E
    Davies, H A
    Ogilvy-Stuart, Amanda L
    Wales, J K
    Shalet, Stephen M
    Affiliation
    Department of Endocrinology, Christie Hospital, NHS Trust, Manchester, United Kingdom.
    Issue Date
    1995-07
    
    Metadata
    Show full item record
    Abstract
    To determine whether obesity complicated the treatment of childhood acute lymphoblastic leukemia, we studied the body mass index (BMI) of 63 female when and 51 male patients from the time of diagnosis of acute lymphoblastic leukemia to the time when final height was attained. The BMI z score was calculated for each patient at diagnosis, at end of treatment, and at attainment of final height. Obesity at attainment of final height was defined as a BMI greater than the 85th percentile of the normal reference population. At final height 23 of 51 male (45%) and 30 of 63 female patients (47%) were obese. Girls became obese between diagnosis and the end of chemotherapy (p = 0.02), after which they had no further increase, indicating that chemotherapy may have played a role in their obesity. Boys had a progressive and gradual increase in BMI z score through to attainment of final height. Obesity did not appear to be associated with growth hormone insufficiency, disproportionate growth, or abnormal timing of puberty. We conclude that approximately half the survivors of leukemia in childhood become obese young adults. Many of those treated with the more recent regimens studied are still only in their mid or preteen years and should be advised regarding a more active lifestyle and a healthy diet in an attempt to reduce the incidence of obesity.
    Citation
    High incidence of obesity in young adults after treatment of acute lymphoblastic leukemia in childhood. 1995, 127 (1):63-7 J. Pediatr.
    Journal
    The Journal of Pediatrics
    URI
    http://hdl.handle.net/10541/98098
    DOI
    10.1016/S0022-3476(95)70258-X
    PubMed ID
    7608813
    Type
    Article
    Language
    en
    ISSN
    0022-3476
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0022-3476(95)70258-X
    Scopus Count
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