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    Chemotherapy with vincristine/ifosfamide/carboplatin/etoposide in small cell lung cancer.

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    Authors
    Lorigan, Paul C
    Lee, Siow Ming
    Betticher, Daniel C
    Woodhead, M
    Weir, D
    Hanley, S
    Hardy, C
    Thatcher, Nick
    Affiliation
    YCRC Department of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
    Issue Date
    1995-06
    
    Metadata
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    Abstract
    Although chemotherapy is considered the cornerstone of treatment for small cell lung cancer (SCLC), the majority of SCLC patients relapse and die of their disease within 2 years of diagnosis. Until newer, more effective drugs are developed, both optimization of available chemotherapeutic regimens and the use of combined chemotherapy/radiotherapy will be required to improve the survival of SCLC patients. Combining ifosfamide, carboplatin, and etoposide, among the most active single agents against SCLC, into the ICE regimen was a logical move that has resulted in improved response and survival rates. In limited and extensive SCLC, respectively, ICE and ICE administered with vincristine (VICE) have achieved overall response rates of 79% to 94% and 77% to 100% and 2-year survival rates of 24% to 33% and 9% to 25%, respectively. Treatment-related toxicities, especially myelosuppression, have hindered efforts to accelerate the administration of ICE and VICE regimens and to incorporate them into combined-modality treatments. However, the use of hematologic support measures, including growth factors and peripheral blood progenitor cells, may pave the way for maximizing the effectiveness of these regimens.
    Citation
    Chemotherapy with vincristine/ifosfamide/carboplatin/etoposide in small cell lung cancer. 1995, 22 (3 Suppl 7):32-41 Semin. Oncol.
    Journal
    Seminars in Oncology
    URI
    http://hdl.handle.net/10541/98066
    PubMed ID
    7610397
    Type
    Article
    Language
    en
    ISSN
    0093-7754
    Collections
    All Christie Publications

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