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dc.contributor.authorMitchell, Erika L D
dc.contributor.authorWhite, Gavin R M
dc.contributor.authorSantibanez-Koref, Mauro F
dc.contributor.authorVarley, Jennifer
dc.contributor.authorHeighway, Jim
dc.date.accessioned2010-05-05T12:28:08Z
dc.date.available2010-05-05T12:28:08Z
dc.date.issued1995-06
dc.identifier.citationMapping of gene loci in the Q13-Q15 region of chromosome 12. 1995, 3 (4):261-2 Chromosome Res.en
dc.identifier.issn0967-3849
dc.identifier.pmid7606365
dc.identifier.doi10.1007/BF00713052
dc.identifier.urihttp://hdl.handle.net/10541/97944
dc.description.abstractThe gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
dc.language.isoenen
dc.subject.meshCCAAT-Enhancer-Binding Proteins
dc.subject.meshChromosome Mapping
dc.subject.meshChromosomes, Human, Pair 12
dc.subject.meshCyclin-Dependent Kinase 4
dc.subject.meshCyclin-Dependent Kinases
dc.subject.meshDNA-Binding Proteins
dc.subject.meshGenetic Markers
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshNuclear Proteins
dc.subject.meshOncogene Proteins
dc.subject.meshProtein-Serine-Threonine Kinases
dc.subject.meshProto-Oncogene Proteins
dc.subject.meshProto-Oncogene Proteins c-mdm2
dc.subject.meshTrans-Activators
dc.subject.meshTranscription Factor CHOP
dc.subject.meshTranscription Factors
dc.titleMapping of gene loci in the Q13-Q15 region of chromosome 12.en
dc.typeArticleen
dc.contributor.departmentCancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.en
dc.identifier.journalChromosome Researchen
html.description.abstractThe gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.


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