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    Effects of IL-11 on the growth of intestinal epithelial cells in vitro.

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    Authors
    Booth, Catherine
    Potten, Christopher S
    Affiliation
    CRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Withington, Manchester, UK.
    Issue Date
    1995-11
    
    Metadata
    Show full item record
    Abstract
    The network of interacting factors that control proliferation in the intestinal epithelium is largely unknown. Recently, IL-11 was found to protect animals from lethal doses of cytotoxic agents. Part of this protective action was ascribed to a reduced level of damage in the intestinal epithelium. Whether this was due to a direct effect on epithelial cell cycle progression was unclear. We have addressed this question in vitro and found that IL-11 reversibly inhibited proliferation in untransformed small intestinal IEC18 cells. However, IL-11 did not inhibit transformed SW620 or HT29 colonic cell lines. IL-6 behaved in a similar manner to IL-11. Thus, these results suggest that IL-11 may be an ideal therapy adjuvant, protecting normal cells and further, these results suggest that IL-11 may be involved in the normal growth controls in the intestinal epithelium. The inhibitory response evoked by IL-11 is lost during carcinogenic transformation.
    Citation
    Effects of IL-11 on the growth of intestinal epithelial cells in vitro. 1995, 28 (11):581-94 Cell Prolif.
    Journal
    Cell Proliferation
    URI
    http://hdl.handle.net/10541/97941
    DOI
    10.1111/j.1365-2184.1995.tb00046.x
    PubMed ID
    8555371
    Type
    Article
    Language
    en
    ISSN
    0960-7722
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2184.1995.tb00046.x
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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