Effects of IL-11 on the growth of intestinal epithelial cells in vitro.
AffiliationCRC Department of Epithelial Biology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Withington, Manchester, UK.
MetadataShow full item record
AbstractThe network of interacting factors that control proliferation in the intestinal epithelium is largely unknown. Recently, IL-11 was found to protect animals from lethal doses of cytotoxic agents. Part of this protective action was ascribed to a reduced level of damage in the intestinal epithelium. Whether this was due to a direct effect on epithelial cell cycle progression was unclear. We have addressed this question in vitro and found that IL-11 reversibly inhibited proliferation in untransformed small intestinal IEC18 cells. However, IL-11 did not inhibit transformed SW620 or HT29 colonic cell lines. IL-6 behaved in a similar manner to IL-11. Thus, these results suggest that IL-11 may be an ideal therapy adjuvant, protecting normal cells and further, these results suggest that IL-11 may be involved in the normal growth controls in the intestinal epithelium. The inhibitory response evoked by IL-11 is lost during carcinogenic transformation.
CitationEffects of IL-11 on the growth of intestinal epithelial cells in vitro. 1995, 28 (11):581-94 Cell Prolif.
- Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation.
- Authors: Peterson RL, Bozza MM, Dorner AJ
- Issue date: 1996 Sep
- IL-4 enhances IEC-6 intestinal epithelial cell proliferation yet has no effect on IL-6 secretion.
- Authors: McGee DW, Vitkus SJ
- Issue date: 1996 Aug
- Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro-evidence for a TGF--beta-mediated effect.
- Authors: Bulut K, Meier JJ, Ansorge N, Felderbauer P, Schmitz F, Hoffmann P, Schmidt WE, Gallwitz B
- Issue date: 2004 Sep 15
- Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide.
- Authors: Schuerer-Maly CC, Eckmann L, Kagnoff MF, Falco MT, Maly FE
- Issue date: 1994 Jan