• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Testicular toxicity of the transferrin binding radionuclide 114mIn in adult and neonatal rats.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Hoyes, Katherine P
    Johnson, C
    Johnston, R E
    Lendon, R G
    Hendry, Jolyon H
    Sharma, H L
    Morris, Ian D
    Affiliation
    Cancer Research Campaign Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    2010-05-05T10:40:26Z
    
    Metadata
    Show full item record
    Abstract
    Adult (70 d) and neonatal (7 d) male rats were dosed (i.p.) with 37 MBq/kg (1 mCi/kg; approximately 1 microgram elemental indium/kg) 114mIn, a transferrin-binding radionuclide. In adults, approximately 0.25% of the injected activity localised within the testis by 48 h postinjection and remained constant for up to 63 d. In neonates, 0.06% of the activity was in the testis by 48 h, and this declined such that by 63 d only 0.03% remained. At 63 d, treated rats had reduced sperm head counts and abnormal testicular histology that was more marked in animals dosed as adults than as neonates. In vitro, uptake of 114mIn into seminiferous tubules isolated from 7-, 20-, or 70-d-old rats was compared with that of 125I. Both radionuclides were readily accumulated by the tubules. Whilst 114In uptake into 20- and 70-d tubules was inhibited by excess transferrin, uptake into 7-d tubules was unchanged. 125I uptake was not affected by excess transferrin. These data support the contention that some radionuclides may cross the blood-testis barrier by utilisation of the physiologic iron-transferrin pathway, which may lead to greater testicular damage in adult compared to neonatal animals.
    Citation
    Testicular toxicity of the transferrin binding radionuclide 114mIn in adult and neonatal rats., 9 (3):297-305 Reprod. Toxicol.
    Journal
    Reproductive Toxicology
    URI
    http://hdl.handle.net/10541/97936
    DOI
    10.1016/0890-6238(95)00012-Y
    PubMed ID
    7579915
    Type
    Article
    Language
    en
    ISSN
    0890-6238
    ae974a485f413a2113503eed53cd6c53
    10.1016/0890-6238(95)00012-Y
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Transferrin-mediated uptake of radionuclides by the testis.
    • Authors: Hoyes KP, Morris ID, Hendry JH, Sharma HL
    • Issue date: 1996 Feb
    • Spermatogenic and mutagenic damage after paternal exposure to systemic indium-114m.
    • Authors: Hoyes KP, Sharma HL, Jackson H, Hendry JH, Morris ID
    • Issue date: 1994 Aug
    • Transferrin-mediated uptake of plutonium by spermatogenic tubules.
    • Authors: Hoyes KP, Bingham D, Hendry JH, Harrison JD, Sharma HL, Morris ID
    • Issue date: 1996 Oct
    • Spermatogenesis and epididymal sperm after scrotal gamma irradiation in adult rats.
    • Authors: Bansal MR, Kaul A, Tewari M, Nehru B
    • Issue date: 1990
    • In vivo induction of O6-alkylguanine-DNA-alkyltransferase in response to indium-114m.
    • Authors: Wilson RE, Hoyes KP, Morris ID, Sharma HL, Hendry JH, Margison GP
    • Issue date: 1994 Apr
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.