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    Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.

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    Authors
    Munn, K E
    Walker, R A
    Varley, Jennifer
    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    1995-04-20
    
    Metadata
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    Abstract
    Ductal carcinoma in situ (DCIS) of the breast is commonly described as a premalignant lesion. Using PCR to amplify DNA from areas of tumour cells which have been microdissected from fixed material, we have studied the involvement of chromosome 1 in 19 cases of DCIS. A series of microsatellite repeat polymorphisms has been used to define regions of allelic imbalance and this has confirmed the involvement in DCIS of six of the regions previously implicated in studies of invasive breast tumours. This suggests that these regions may harbour tumour suppressor genes, the inactivation of which is important for the early stages of breast tumour development. Analysis of separate ducts from within the same tumour has revealed that the same genetic alterations are not necessarily present throughout the lesion. In addition we have found that in three cases where frank invasive carcinoma is also present, similar alterations can be detected in the in situ and invasive component.
    Citation
    Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast. 1995, 10 (8):1653-7 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/97777
    PubMed ID
    7731721
    Type
    Article
    Language
    en
    ISSN
    0950-9232
    Collections
    All Paterson Institute for Cancer Research

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