Frequent alterations of chromosome 1 in ductal carcinoma in situ of the breast.
AffiliationCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
MetadataShow full item record
AbstractDuctal carcinoma in situ (DCIS) of the breast is commonly described as a premalignant lesion. Using PCR to amplify DNA from areas of tumour cells which have been microdissected from fixed material, we have studied the involvement of chromosome 1 in 19 cases of DCIS. A series of microsatellite repeat polymorphisms has been used to define regions of allelic imbalance and this has confirmed the involvement in DCIS of six of the regions previously implicated in studies of invasive breast tumours. This suggests that these regions may harbour tumour suppressor genes, the inactivation of which is important for the early stages of breast tumour development. Analysis of separate ducts from within the same tumour has revealed that the same genetic alterations are not necessarily present throughout the lesion. In addition we have found that in three cases where frank invasive carcinoma is also present, similar alterations can be detected in the in situ and invasive component.
CitationFrequent alterations of chromosome 1 in ductal carcinoma in situ of the breast. 1995, 10 (8):1653-7 Oncogene
- Characterization of extensive genetic alterations in ductal carcinoma in situ by fluorescence in situ hybridization and molecular analysis.
- Authors: Murphy DS, Hoare SF, Going JJ, Mallon EE, George WD, Kaye SB, Brown R, Black DM, Keith WN
- Issue date: 1995 Nov 15
- Loss of heterozygosity at chromosome 9p in ductal carcinoma in situ and invasive carcinoma of the breast.
- Authors: Marsh KL, Varley JM
- Issue date: 1998 May
- Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast.
- Authors: Buerger H, Simon R, Schäfer KL, Diallo R, Littmann R, Poremba C, van Diest PJ, Dockhorn-Dworniczak B, Böcker W
- Issue date: 2000 Jun
- Chromosomal alterations associated with the transition from in situ to invasive breast cancer.
- Authors: Ellsworth RE, Vertrees A, Love B, Hooke JA, Ellsworth DL, Shriver CD
- Issue date: 2008 Sep
- Microsatellite alterations on human chromosome 11 in in situ and invasive breast cancer: a microdissection microsatellite analysis and correlation with p53, ER (estrogen receptor), and PR (progesterone receptor) protein immunoreactivity.
- Authors: Shen KL, Yang LS, Hsieh HF, Chen CJ, Yu JC, Tsai NM, Harn HJ
- Issue date: 2000 Jun