• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Just, Ursula
    Kan, On
    Fennelly, Jan
    Dexter, T Michael
    Spooncer, Elaine
    Affiliation
    Department of Experimental Haematology, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    1995
    
    Metadata
    Show full item record
    Abstract
    The establishment of IL-3-dependent multipotent progenitor cell lines from Hox-2.4-expressing bone marrow cells suggests that homeobox genes may contribute to immortalization of early myeloid cells. A survey of 20 independently derived multipotent IL-3-dependent cell lines established from either src-virus-infected long-term bone marrow cultures (FDCP-mix) or Multi-CSF-virus (M3MuV)-infected bone marrow revealed that Hox-2.4 was not expressed in any of these cell lines. In addition DNA rearrangements were not observed. We conclude that activation of Hox-2.4 is not an obligatory event in the immortalization of early myeloid cells.
    Citation
    The Hox-2.4 gene is not involved in the generation of IL-3 dependent multipotent FDCP-mix cell lines. 1995, 12 (3):173-7 Growth Factors
    Journal
    Growth Factors
    URI
    http://hdl.handle.net/10541/97477
    DOI
    10.3109/08977199509036877
    PubMed ID
    8619923
    Type
    Article
    Language
    en
    ISSN
    0897-7194
    ae974a485f413a2113503eed53cd6c53
    10.3109/08977199509036877
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Conditional immortalization of mouse myelomonocytic, megakaryocytic and mast cell progenitors by the Hox-2.4 homeobox gene.
    • Authors: Perkins AC, Cory S
    • Issue date: 1993 Oct
    • Targeted in vivo infection with a retroviral vector carrying the interleukin-3 (multi-CSF) gene leads to immortalization and leukemic transformation of primitive hematopoietic progenitor cells.
    • Authors: Just U, Katsuno M, Stocking C, Spooncer E, Dexter M
    • Issue date: 1993
    • Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis.
    • Authors: Wheadon H, Ramsey JM, Dobbin E, Dickson GJ, Corrigan PM, Freeburn RW, Thompson A
    • Issue date: 2011 Aug
    • Murine interleukin 9 stimulates the proliferation of mouse erythroid progenitor cells and favors the erythroid differentiation of multipotent FDCP-mix cells.
    • Authors: Bourette RP, Royet J, Mouchiroud G, Schmitt E, Blanchet JP
    • Issue date: 1992 Aug
    • Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation.
    • Authors: Pettersson M, Dannaeus K, Nilsson K, Jönsson JI
    • Issue date: 2000 Mar
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.