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    Loss of heterozygosity on the X chromosome in human breast cancer.

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    Authors
    Loupart, M L
    Adams, S
    Armour, J A
    Walker, R
    Brammar, W
    Varley, Jennifer
    Affiliation
    ICI/University Joint Laboratory, University of Leicester, United Kingdom.
    Issue Date
    1995-08
    
    Metadata
    Show full item record
    Abstract
    The analysis of loss of heterozygosity (LOH) in tumours can be a powerful tool for mapping the sites of tumour suppressor genes in the human genome. A panel of breast cancer patients was assembled as pairs of tumour and lymphocyte DNA samples and LOH studies carried out by Southern hybridisation with polymorphic loci mapping to the X chromosome with appropriate controls. Deletion mapping revealed a high frequency of small regionalised deletions, defining at least three independent regions, one of which is particularly well mapped to a 500 kb stretch of DNA in the distal portion of the pseudoautosomal region of Xp. A second region has been identified within the pseudoautosomal region close to the pseudoautosomal boundary, and there is a third discrete site of loss on distal Xq. Perturbations of sequences at these regions represent independent events in a number of patients. This study represents the first detailed analysis of LOH on the X chromosome in human breast tumours, the results of which indicate that at least three regions of this chromosome are involved in the disease.
    Citation
    Loss of heterozygosity on the X chromosome in human breast cancer. 1995, 13 (4):229-38 Genes Chromosomes Cancer
    Journal
    Genes, Chromosomes & Cancer
    URI
    http://hdl.handle.net/10541/97476
    DOI
    10.1002/gcc.2870130402
    PubMed ID
    7547630
    Type
    Article
    Language
    en
    ISSN
    1045-2257
    ae974a485f413a2113503eed53cd6c53
    10.1002/gcc.2870130402
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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