The interaction with tubulin of a series of stilbenes based on combretastatin A-4.
dc.contributor.author | Woods, J A | |
dc.contributor.author | Hadfield, John A | |
dc.contributor.author | Pettit, G R | |
dc.contributor.author | Fox, Brian W | |
dc.contributor.author | McGown, Alan T | |
dc.date.accessioned | 2010-04-27T13:59:27Z | |
dc.date.available | 2010-04-27T13:59:27Z | |
dc.date.issued | 1995-04 | |
dc.identifier.citation | The interaction with tubulin of a series of stilbenes based on combretastatin A-4. 1995, 71 (4):705-11 Br. J. Cancer | en |
dc.identifier.issn | 0007-0920 | |
dc.identifier.pmid | 7710932 | |
dc.identifier.uri | http://hdl.handle.net/10541/97461 | |
dc.description.abstract | A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type. | |
dc.language.iso | en | en |
dc.subject | Leukaemia P388 | en |
dc.subject | Cultured Tumour Cells | en |
dc.subject.mesh | Animals | |
dc.subject.mesh | Antineoplastic Agents, Phytogenic | |
dc.subject.mesh | Binding, Competitive | |
dc.subject.mesh | Cell Cycle | |
dc.subject.mesh | Leukemia P388 | |
dc.subject.mesh | Mice | |
dc.subject.mesh | Microtubules | |
dc.subject.mesh | Mitotic Index | |
dc.subject.mesh | Molecular Structure | |
dc.subject.mesh | Stilbenes | |
dc.subject.mesh | Structure-Activity Relationship | |
dc.subject.mesh | Thermodynamics | |
dc.subject.mesh | Tubulin | |
dc.subject.mesh | Tumor Cells, Cultured | |
dc.title | The interaction with tubulin of a series of stilbenes based on combretastatin A-4. | en |
dc.type | Article | en |
dc.contributor.department | CRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK. | en |
dc.identifier.journal | British Journal of Cancer | en |
html.description.abstract | A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type. |