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dc.contributor.authorWoods, J A
dc.contributor.authorHadfield, John A
dc.contributor.authorPettit, G R
dc.contributor.authorFox, Brian W
dc.contributor.authorMcGown, Alan T
dc.date.accessioned2010-04-27T13:59:27Z
dc.date.available2010-04-27T13:59:27Z
dc.date.issued1995-04
dc.identifier.citationThe interaction with tubulin of a series of stilbenes based on combretastatin A-4. 1995, 71 (4):705-11 Br. J. Canceren
dc.identifier.issn0007-0920
dc.identifier.pmid7710932
dc.identifier.urihttp://hdl.handle.net/10541/97461
dc.description.abstractA series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.
dc.language.isoenen
dc.subjectLeukaemia P388en
dc.subjectCultured Tumour Cellsen
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents, Phytogenic
dc.subject.meshBinding, Competitive
dc.subject.meshCell Cycle
dc.subject.meshLeukemia P388
dc.subject.meshMice
dc.subject.meshMicrotubules
dc.subject.meshMitotic Index
dc.subject.meshMolecular Structure
dc.subject.meshStilbenes
dc.subject.meshStructure-Activity Relationship
dc.subject.meshThermodynamics
dc.subject.meshTubulin
dc.subject.meshTumor Cells, Cultured
dc.titleThe interaction with tubulin of a series of stilbenes based on combretastatin A-4.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Experimental Chemotherapy, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalBritish Journal of Canceren
html.description.abstractA series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type.


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