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    A program using loss-of-constitutional-heterozygosity data to ascertain the location of predisposing genes in cancer families.

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    Authors
    Rohde, K
    Teare, M Dawn
    Scherneck, S
    Santibanez-Koref, Mauro F
    Affiliation
    Department of Bioinformatics, Max Delbrück Centre for Molecular Medicine, Berlin Buch, Germany.
    Issue Date
    2010-04-27T11:11:15Z
    
    Metadata
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    Abstract
    We present a modification of the MLINK program, which enables the formal incorporation of data on loss of constitutional heterozygosity (LOCH) into likelihood calculations. This is an implementation of a previously described approach to localise tumour suppressor genes involved in inherited cancer predisposition. LOCH data are treated as additional observations on disease phenotype. The main effect of including extra data is to enhance the power to detect linkage. In this way, the method facilitates the use of small families, in particular parent-offspring pairs, which would otherwise be uninformative. The technique also has an advantage in view of the increasing use of archival material, which is often derived from specimens taken for histopathological analysis, and may contain tumour tissue which can also be used to obtain additional information. We describe the use of the program, the interpretation of the results and the advantages and limitations of this approach.
    Citation
    A program using loss-of-constitutional-heterozygosity data to ascertain the location of predisposing genes in cancer families., 45 (6):337-45 Hum. Hered.
    Journal
    Human Heredity
    URI
    http://hdl.handle.net/10541/97438
    DOI
    10.1159/000154302
    PubMed ID
    8537081
    Type
    Article
    Language
    en
    ISSN
    0001-5652
    ae974a485f413a2113503eed53cd6c53
    10.1159/000154302
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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