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dc.contributor.authorStack, Maria
dc.contributor.authorJones, David
dc.contributor.authorWhite, Gavin R M
dc.contributor.authorLiscia, D S
dc.contributor.authorVenesio, T
dc.contributor.authorCasey, G
dc.contributor.authorCrichton, D
dc.contributor.authorVarley, Jennifer
dc.contributor.authorMitchell, Erika L D
dc.contributor.authorHeighway, Jim
dc.contributor.authorSantibanez-Koref, Mauro F
dc.date.accessioned2010-04-27T11:07:16Z
dc.date.available2010-04-27T11:07:16Z
dc.date.issued1995-11
dc.identifier.citationDetailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. 1995, 4 (11):2047-55 Hum. Mol. Genet.en
dc.identifier.issn0964-6906
dc.identifier.pmid8589680
dc.identifier.doi10.1093/hmg/4.11.2047
dc.identifier.urihttp://hdl.handle.net/10541/97437
dc.description.abstractThe chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.
dc.language.isoenen
dc.subjectBreast Canceren
dc.subjectTumour Suppressor Genesen
dc.subject.meshBase Sequence
dc.subject.meshBreast Neoplasms
dc.subject.meshChromosome Banding
dc.subject.meshChromosome Deletion
dc.subject.meshChromosome Mapping
dc.subject.meshChromosomes, Artificial, Yeast
dc.subject.meshChromosomes, Human, Pair 17
dc.subject.meshFemale
dc.subject.meshGenes, Tumor Suppressor
dc.subject.meshHeterozygote
dc.subject.meshHumans
dc.subject.meshIn Situ Hybridization, Fluorescence
dc.subject.meshMolecular Sequence Data
dc.titleDetailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.en
dc.typeArticleen
dc.contributor.departmentCRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.en
dc.identifier.journalHuman Molecular Geneticsen
html.description.abstractThe chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.


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