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    Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3.

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    Authors
    Stack, Maria
    Jones, David
    White, Gavin R M
    Liscia, D S
    Venesio, T
    Casey, G
    Crichton, D
    Varley, Jennifer
    Mitchell, Erika L D
    Heighway, Jim
    Santibanez-Koref, Mauro F
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    Affiliation
    CRC Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital, Manchester, UK.
    Issue Date
    1995-11
    
    Metadata
    Show full item record
    Abstract
    The chromosome region 17p13.3 is thought to encode a tumour suppressor gene involved in sporadic breast cancer and other malignancies. Physical ordering of markers has been carried out by a series of multicolour fluorescent in situ hybridisation (FISH) experiments, using isolated yeast artificial chromosomes (YACs) and cosmids. Eight polymorphic markers ordered within this new physical map and one external marker were used to investigate the pattern of loss of heterozygosity in a panel of 40 sporadic breast tumour patients. The data revealed a region of high loss (60%) within distal 17p13.3, defined by markers D17S926, D17S695 and D17S849 which mapped close together. A contig of YACs was constructed physically linking these three markers.
    Citation
    Detailed mapping and loss of heterozygosity analysis suggests a suppressor locus involved in sporadic breast cancer within a distal region of chromosome band 17p13.3. 1995, 4 (11):2047-55 Hum. Mol. Genet.
    Journal
    Human Molecular Genetics
    URI
    http://hdl.handle.net/10541/97437
    DOI
    10.1093/hmg/4.11.2047
    PubMed ID
    8589680
    Type
    Article
    Language
    en
    ISSN
    0964-6906
    ae974a485f413a2113503eed53cd6c53
    10.1093/hmg/4.11.2047
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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