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    Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?

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    Authors
    Vereb, G
    Mátyus, L
    Bene, L
    Panyi, G
    Bacsó, Z
    Balázs, M
    Matkó, J
    Szöllösi, J
    Gáspár, R
    Damjanovich, S
    Dale, Robert E
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    Affiliation
    Department of Biophysics, University Medical School of Debrecen, Hungary.
    Issue Date
    1995
    
    Metadata
    Show full item record
    Abstract
    Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.
    Citation
    Plasma-membrane-bound macromolecules are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?, 8 (4):237-46 J. Mol. Recognit.
    Journal
    Journal of Molecular Recognition
    URI
    http://hdl.handle.net/10541/97420
    DOI
    10.1002/jmr.300080402
    PubMed ID
    8588941
    Type
    Article
    Language
    en
    ISSN
    0952-3499
    ae974a485f413a2113503eed53cd6c53
    10.1002/jmr.300080402
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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